High impact information on LOC423015

• Secretin had a minimal effect on cyclic AMP accumulation even at a very high (5 X 10(-6) M) concentration [1].
• The reason for PCT's apparent potency was due to trace contamination of thyroid hormone in the PCT preparation, since synthetic PCT caused an increase in cartilage wet weight equivalent to those produced by SCT and HCT [2].
• The infusion of chicken secretin reduced the flow of juice in response to infusions of chicken VIP, but the differences were not significant [3].
• There was no significant difference in either the rate of flow, or rate of protein secretion from the turkey pancreas in response to an infusion of chicken secretin and CCK8, compared with CCK8 alone [3].
• Comparison of the actions of porcine secretin and extracts of chicken duodenum on pancreatic exocrine secretion in the cat and turkey [4].

Biological context of LOC423015

• Studies on peptides. CXIII. Synthesis of the heptacosapeptide amide corresponding to the entire amino acid sequence of chicken secretin [5].
• Chicken VIP and porcine secretin exhibited a 7-fold higher and a 7-fold lower affinity than porcine VIP for binding sites, respectively [6].

Anatomical context of LOC423015

• The relative rank order of potency of the tested peptides to inhibit [125I]-PACAP27 binding to chick cerebrum was: PACAP38 approximately PACAP27>PACAP6-27 approximately PACAP6-38 >> chicken VIP >> mammalian VIP >> secretin (inactive) [7].
• Effects of neuropeptides of the secretin/VIP/PACAP family on cyclic AMP formation in the chick hypothalamus and cerebral cortex [8].

Associations of LOC423015 with chemical compounds

• 1. Extracts were prepared of chicken duodenum and their actions on pancreatic secretion in urethane anasthetized turkeys and in conscious cats were compared with those of pure natural porcine secretin [4].
• The heptacosapeptide amide corresponding to the entire amino acid sequence of chicken secretin was synthesized by assembling four peptide fragments followed by deprotection with thioanisole-mediated trifluoromethanesulfonic acid in TFA [5].
• It is stimulated by phlorizin, a potent inhibitor of sugar transport, and in Na+-leached tissue by modifiers of tissue cyclic AMP levels, e.g. theophylline, histamine, carbachol and secretin [9].
• Tests for alignments among different groups of peptides revealed similarities between bombesin and glucagon or secretin, as well as between caerulein and litorin [10].

Other interactions of LOC423015

• Chicken secretin further shows a clear structural similarity to the vasoactive intestinal peptide (37% identical positions), the gastric inhibitory peptide (30% identical positions) and to glucagon (52% identical positions), suggesting wide evolutionary and functional relationships [11].
• The influence of saline infusion (i.v.) followed by infusion of either cholecystokinin, vasoactive intestinal peptide, or secretin on plasma concentration of avian pancreatic polypeptide (aPP) was studied in sixteen 18-26-week old Single Comb White Leghorn hens [12].

References