Gene Review:
SIRT1 - sirtuin 1
Gallus gallus
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High impact information on SIRT1
- Cells rendered doubly deficient in SIRT1 and SIRT2 exhibited the same levels of IR and cisplatin sensitivity as SIRT1-/- cells [1].
- Our results indicate that SIRT1 and SIRT2 regulate stress-induced cell death pathways in a p53-independent manner [1].
Biological context of SIRT1
- SIRT1-/- cells appeared to be defective neither in DNA double strand break repair nor in G2/M checkpoints, but were more susceptible to cell death induction following IR than wild-type cells [1].
Associations of SIRT1 with chemical compounds
- Furthermore, both SIRT1- and SIRT2-deficient cells were more sensitive to pro-apoptotic stimuli including cisplatin and staurosporine [1].
Other interactions of SIRT1
References
- Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells. Matsushita, N., Takami, Y., Kimura, M., Tachiiri, S., Ishiai, M., Nakayama, T., Takata, M. Genes Cells (2005) [Pubmed]
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