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Gene Review

EloB  -  Elongin B

Drosophila melanogaster

Synonyms: CG4204, Dmel\CG4204, Elongin-B
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High impact information on Elongin-B

  • Elongin A, the largest subunit of the elongin complex, is the transcriptionally active subunit, while the smaller elongin B and C subunits appear to act as regulatory subunits [1].
  • In this report, we show that the Elongin B ubiquitin-like domain is necessary and sufficient for interaction with Elongin C and for positive regulation of Elongin A transcriptional activity [2].

Analytical, diagnostic and therapeutic context of Elongin-B


  1. In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development. Gerber, M., Eissenberg, J.C., Kong, S., Tenney, K., Conaway, J.W., Conaway, R.C., Shilatifard, A. Mol. Cell. Biol. (2004) [Pubmed]
  2. The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C. Brower, C.S., Shilatifard, A., Mather, T., Kamura, T., Takagi, Y., Haque, D., Treharne, A., Foundling, S.I., Conaway, J.W., Conaway, R.C. J. Biol. Chem. (1999) [Pubmed]
  3. Molecular cloning of DNAs encoding the regulatory subunits of elongin from Saccharomyces cerevisiae and Drosophila melanogaster. Aso, T., Conrad, M.N. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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