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Gene Review

DCTN1  -  dynactin 1

Gallus gallus

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High impact information on DCTN1


Anatomical context of DCTN1

  • In many cases, there is compelling evidence that dynactin functions in part to attach dyneins to cargo organelles, but this may not always be the case [2].

Analytical, diagnostic and therapeutic context of DCTN1


  1. A microtubule-binding domain in dynactin increases dynein processivity by skating along microtubules. Culver-Hanlon, T.L., Lex, S.A., Stephens, A.D., Quintyne, N.J., King, S.J. Nat. Cell Biol. (2006) [Pubmed]
  2. Immunolocalization of cytoplasmic dynein and dynactin subunits in cultured macrophages: enrichment on early endocytic organelles. Habermann, A., Schroer, T.A., Griffiths, G., Burkhardt, J.K. J. Cell. Sci. (2001) [Pubmed]
  3. Two-dimensional averaged images of the dynactin complex revealed by single particle analysis. Imai, H., Narita, A., Schroer, T.A., Maéda, Y. J. Mol. Biol. (2006) [Pubmed]
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