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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

B-G  -  MHC class IV antigen

Gallus gallus

 
 
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High impact information on B-G

  • The chicken major histocompatibility complex (MHC) is commonly defined by serologic reactions of erythrocytes with antibodies specific to the highly polymorphic MHC class I (BF) and MHC class IV (BG) antigens [1].
  • The humoral response in another pair of recombinant haplotypes originating in 2 different White Leghorn chickens being BF21, BL21, BG15 (BR4) and BF15, BL15, BG21 (BR5) on the MHC locus indicated that the BG locus may perform an adjuvant effect on the antibody response as well [2].
  • The humoral response of 1 pair of recombinants isolated from a Red Jungle Fowl (BW3 and BW4) being identical on BF and BG, but different on BL, indicated that part of the primary vaccine response was an MHC II restricted T-cell dependent response [2].
  • BACKGROUND: The quail and chicken major histocompatibility complex (Mhc) genomic regions have a similar overall organization but differ markedly in that the quail has an expanded number of duplicated class I, class IIB, natural killer (NK)-receptor-like, lectin-like and BG genes [3].
 

Biological context of B-G

  • The microsatellite marker LEI0258 is known to be physically located within the MHC, between the BG and BF regions [1].

References

  1. Molecular genotype identification of the Gallus gallus major histocompatibility complex. Fulton, J.E., Juul-Madsen, H.R., Ashwell, C.M., McCarron, A.M., Arthur, J.A., O'Sullivan, N.P., Taylor, R.L. Immunogenetics (2006) [Pubmed]
  2. Immune response to a killed infectious bursal disease virus vaccine in inbred chicken lines with different major histocompatibility complex haplotypes. Juul-Madsen, H.R., Dalgaard, T.S., Røntved, C.M., Jensen, K.H., Bumstead, N. Poult. Sci. (2006) [Pubmed]
  3. The major histocompatibility complex (Mhc) class IIB region has greater genomic structural flexibility and diversity in the quail than the chicken. Hosomichi, K., Shiina, T., Suzuki, S., Tanaka, M., Shimizu, S., Iwamoto, S., Hara, H., Yoshida, Y., Kulski, J.K., Inoko, H., Hanzawa, K. BMC Genomics (2006) [Pubmed]
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