High impact information on EloA

• Elongin A, the largest subunit of the elongin complex, is the transcriptionally active subunit, while the smaller elongin B and C subunits appear to act as regulatory subunits [1].
• The discovery of the role of elongin A in an in vivo model system defines the novel contribution played by RNA polymerase II elongation machinery in regulation of gene expression that is required for proper development [1].
• The goal of this study was to test whether dEloA is required for heat shock gene transcription, since heat shock gene expression is thought to be controlled at the level of Pol II elongation [2].
• Furthermore, through the use of RNA interference in vivo, we show that dEloA is required for the proper expression of one of these genes, HSP70, and that its requirement for heat shock gene expression is exerted after the initiation of transcription at heat shock loci [2].
• Regulation of heat shock gene expression by RNA polymerase II elongation factor, Elongin A [2].

Physical interactions of EloA

• The recombinant yeast Elongin C protein interacts with both mammalian Elongin A and VHL tumor suppressor protein [3].

Regulatory relationships of EloA

• Moreover, yeast Elongin C strongly induces the transcriptional elongation activity of mammalian Elongin A [3].

Other interactions of EloA

• The Elongin complex is a potential target for regulation by the von Hippel-Lindau (VHL) tumor suppressor protein, which is capable of binding stably to the Elongin BC complex and preventing it from activating Elongin A [3].

References