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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

DDX4  -  DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

Sus scrofa

 
 
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Disease relevance of DDX4

  • Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia [1].
  • The three-dimensional anatomy of the vasa vasorum in early coronary atherosclerosis is unknown [1].
  • The density of newly formed vasa vasorum was proportional to vessel stenosis (r = 0.81, p = 0.0001) [2].
  • Recent evidence suggests a role for the vasa vasorum (VV) in vascular disease [3].
  • Mural ischemia alone resulted in necrosis of cells in the medial zone furnished by vasa but did not lead to aneurysmal dilatation, and all the fibrous tissue layers persisted during the 2-month observation period [4].
 

Psychiatry related information on DDX4

  • This occurred especially by an increase of second-order vasa vasorum and disorientation of normal vasa vasorum spatial pattern [1].
 

High impact information on DDX4

  • Coronary arteries contain a network of vasa vasorum in the adventitia [1].
  • Smooth muscle cells were enzymatically dispersed from vasa deferentia of adult male guinea pigs (250-400 g) [5].
  • Endothelin-1 (ET) is a potent vasoconstrictor of vasa nervorum, the vascular supply of peripheral nerve trunks, that may, through elevated circulating levels, promote microangiopathy in human diabetes patients [6].
  • The hepatic artery supplies oxygenated blood to five stromal compartments: peribiliary vascular plexus, portal tract interstitium, portal vein vasa vasorum, hepatic capsule, and central-sublobular-hepatic vein vasa vasorum [7].
  • METHODS: Arterial vasa vasorum were dissected from the walls of porcine or bovine thoracic aorta and mounted in a tension myograph [8].
 

Chemical compound and disease context of DDX4

 

Biological context of DDX4

  • The present experiments were undertaken to explore, under acute in vitro conditions, the relationship between membrane potential changes and sensitivity in the vasa deferentia of guinea pigs and rats [12].
  • When the pressure release reflector was used, the morphological lesion was limited to hemorrhage of vasa recta vessels near the tips of renal papillae and the only change in kidney function was a decrease in the glomerular filtration rate at the 1 and 4-hour periods in shock wave treated kidneys [13].
  • Collateral circulation in experimental coarctation of the aorta in minipigs: a possible association with hypertrophied vasa vasorum [14].
 

Anatomical context of DDX4

  • Characterization of pig vasa homolog gene and specific expression in germ cell lineage [15].
  • This study suggests that adventitial neovascularization of vasa vasorum occurs in experimental hypercholesterolemic coronary arteries and may be a part of the early atherosclerotic remodeling process [1].
  • OBJECTIVE: The vasa vasorum form a network of microvessels in and around the walls of large blood vessels and are thought to be necessary to delivery oxygenated blood to the outer parts of the vessel wall that are inadequately nourished by diffusion from luminal blood [8].
  • 1 The walls of certain large blood vessels are nourished by the vasa vasorum, a network of microvessels that penetrate the adventitia and media of the vessel wall [16].
  • These results may have important implications for baroreceptor sensitivity, circulation of the vasa vasorum, and coronary dissection [17].
 

Associations of DDX4 with chemical compounds

  • SP and BK produced endothelium-dependent relaxation while CGRP produced endothelium-independent relaxation of ET-1-precontracted vasa vasorum [8].
  • Vasa deferentia dissected from animals treated with reserpine release ATP, r-ATPase, and r-AMPase, whereas the overflow of NE is completely abolished [18].
  • Using cryostatic microscopic computed tomography (micro-CT), we sought to determine the role of coronary vasa vasorum (VV) in transendothelial solute transport in arteries with normal and increased permeability due to high plasma cholesterol levels [19].
  • 4 ET-1 (1-3 nM) enhanced responses to noradrenaline (NA) (4 fold) but not to thromboxane A2-mimetic, whilst K+ (10-20 mM) sensitized vasa to both types of constrictor [16].
  • Differences in the effects of lowered extracellular potassium concentration or ouabain on resting membrane potential (preceding paper) are apparently unrelated to the amount of transport enzyme in the vasa deferentia or the two species, or to its relative sensitivity to ouabain [20].
 

Analytical, diagnostic and therapeutic context of DDX4

  • After 12 weeks, coronary vasa vasorum structure was assessed by three-dimensional microscopic computed tomography, expression of vascular endothelial growth factor (VEGF) within the coronary arterial wall by Western blotting and immunostaining [21].
  • In this study, we elucidate functional aspects of coronary vasa vasorum perfusion territories [22].
  • Microembolization reduced vasa vasorum densities significantly (100-mum-diameter microspheres: 3.26 +/- 0.07 vasa/mm2, P < 0.05; 300-microm-diameter microspheres: 2.66 +/- 0.07 vasa/mm2, P < 0.001 vs. antegrade controls) and increased the size of low-vasa-vasorum-density territories [22].
  • Histologic examination of the vasa revealed morphologic changes in some AID animals, these being attributed to the vasectomy procedure [23].
  • Absorbable intravas devices (AID) were inserted into the vasa at the time of vasovasostomy and produced a return of normal semen quality in 73% of the experimental animals as compared with only 40% in the control group [23].

References

  1. Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia. Kwon, H.M., Sangiorgi, G., Ritman, E.L., McKenna, C., Holmes, D.R., Schwartz, R.S., Lerman, A. J. Clin. Invest. (1998) [Pubmed]
  2. Adventitial vasa vasorum in balloon-injured coronary arteries: visualization and quantitation by a microscopic three-dimensional computed tomography technique. Kwon, H.M., Sangiorgi, G., Ritman, E.L., Lerman, A., McKenna, C., Virmani, R., Edwards, W.D., Holmes, D.R., Schwartz, R.S. J. Am. Coll. Cardiol. (1998) [Pubmed]
  3. Adventitial vasa vasorum heterogeneity among different vascular beds. Galili, O., Herrmann, J., Woodrum, J., Sattler, K.J., Lerman, L.O., Lerman, A. J. Vasc. Surg. (2004) [Pubmed]
  4. Role of medial lamellar architecture in the pathogenesis of aortic aneurysms. Zatina, M.A., Zarins, C.K., Gewertz, B.L., Glagov, S. J. Vasc. Surg. (1984) [Pubmed]
  5. Electrophysiological recordings from spontaneously contracting reaggregates of cultured smooth muscle cells from guinea pig vas deferens. McLean, M.J., Pelleg, A., Sperelakis, N. J. Cell Biol. (1979) [Pubmed]
  6. Diabetes increases sciatic nerve susceptibility to endothelin-induced ischemia. Zochodne, D.W., Cheng, C., Sun, H. Diabetes (1996) [Pubmed]
  7. Liver microvascular architecture: an insight into the pathophysiology of portal hypertension. Ekataksin, W., Kaneda, K. Semin. Liver Dis. (1999) [Pubmed]
  8. On the regulation of tone in vasa vasorum. Scotland, R., Vallance, P., Ahluwalia, A. Cardiovasc. Res. (1999) [Pubmed]
  9. Intimacy of the neuroeffector junction and resistance to alpha-adrenoceptor-blockade of the neurogenic contractile response in vasa deferentia from guinea pig and rat. Hammarström, M., Sjöstrand, N.O. Acta Physiol. Scand. (1984) [Pubmed]
  10. Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering. Wilson, S.H., Herrmann, J., Lerman, L.O., Holmes, D.R., Napoli, C., Ritman, E.L., Lerman, A. Circulation (2002) [Pubmed]
  11. Arterial wall oxygen consumption rate varies spatially. Buerk, D.G., Goldstick, T.K. Am. J. Physiol. (1982) [Pubmed]
  12. The effects of ouabain and alterations in potassium concentration on the sensitivity to drugs and the membrane potential of the smooth muscle of the guinea-pig and rat vas deferens. Urquilla, P.R., Westfall, D.P., Goto, K., Fleming, W.W. J. Pharmacol. Exp. Ther. (1978) [Pubmed]
  13. Kidney damage and renal functional changes are minimized by waveform control that suppresses cavitation in shock wave lithotripsy. Evan, A.P., Willis, L.R., McAteer, J.A., Bailey, M.R., Connors, B.A., Shao, Y., Lingeman, J.E., Williams, J.C., Fineberg, N.S., Crum, L.A. J. Urol. (2002) [Pubmed]
  14. Collateral circulation in experimental coarctation of the aorta in minipigs: a possible association with hypertrophied vasa vasorum. Aguirre-Sanceledonio, M., Fossum, T.W., Miller, M.W., Humphrey, J.D., Berridge, B.R., Herráez, P. J. Comp. Pathol. (2003) [Pubmed]
  15. Characterization of pig vasa homolog gene and specific expression in germ cell lineage. Lee, G.S., Kim, H.S., Lee, S.H., Kang, M.S., Kim, D.Y., Lee, C.K., Kang, S.K., Lee, B.C., Hwang, W.S. Mol. Reprod. Dev. (2005) [Pubmed]
  16. Endothelin alters the reactivity of vasa vasorum: mechanisms and implications for conduit vessel physiology and pathophysiology. Scotland, R., Vallance, P., Ahluwalia, A. Br. J. Pharmacol. (1999) [Pubmed]
  17. Shear modulus of porcine coronary artery: contributions of media and adventitia. Lu, X., Yang, J., Zhao, J.B., Gregersen, H., Kassab, G.S. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  18. Correlation between the release of the sympathetic neurotransmitter ATP and soluble nucleotidases from the guinea pig vas deferens. Mihaylova-Todorova, S., Todorov, L.D., Westfall, D.P. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  19. Role of vasa vasorum in transendothelial solute transport in the coronary vessel wall: a study with cryostatic micro-CT. Gössl, M., Beighley, P.E., Malyar, N.M., Ritman, E.L. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  20. Species differences in sodium-potassium adenosine triphosphatase activity in the smooth muscle of the guinea-pig and rat vas deferens. Fedan, J.S., Westfall, D.P., Fleming, W.W. J. Pharmacol. Exp. Ther. (1978) [Pubmed]
  21. Chronic endothelin receptor antagonism prevents coronary vasa vasorum neovascularization in experimental hypercholesterolemia. Herrmann, J., Best, P.J., Ritman, E.L., Holmes, D.R., Lerman, L.O., Lerman, A. J. Am. Coll. Cardiol. (2002) [Pubmed]
  22. Impact of coronary vasa vasorum functional structure on coronary vessel wall perfusion distribution. Gõssl, M., Malyar, N.M., Rosol, M., Beighley, P.E., Ritman, E.L. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  23. Vasovasostomy and vas occlusion: preliminary observations using artificial devices in guinea pigs. Mohr, K.L., Johnson, P.T. Fertil. Steril. (1978) [Pubmed]
 
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