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Gene Review

Cul5  -  Cullin 5

Drosophila melanogaster

Synonyms: CG1401, CUL5, Cul-5, Cullin5, Dmel\CG1401, ...
 
 
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High impact information on cul-5

  • We decided to examine the phenotypes of Cul-5 aberrations in two well-studied developmental systems: the neuromuscular junction (NMJ) and the developing sensory organ [1].
  • We describe a developmental analysis of Drosophila Cullin-5 (Cul-5) identified from the genome sequence on the basis of its high degree of homology to vertebrate and worm sequences [1].
  • Of great interest is the effect of melatonin upon the expression of a large number of genes related to calcium exchange, such as Cul5, Dcamkl1 and Kcnn4; a significant effect of melatonin on the expression of some oncogenesis-related genes was also detected [2].
 

Biological context of cul-5

  • Such phenotypes highlight the multiple cellular processes in which Cul-5 can participate [1].

References

  1. Cullin-5 plays multiple roles in cell fate specification and synapse formation during Drosophila development. Ayyub, C., Sen, A., Gonsalves, F., Badrinath, K., Bhandari, P., Shashidhara, L.S., Krishna, S., Rodrigues, V. Dev. Dyn. (2005) [Pubmed]
  2. Melatonin as antioxidant, geroprotector and anticarcinogen. Anisimov, V.N., Popovich, I.G., Zabezhinski, M.A., Anisimov, S.V., Vesnushkin, G.M., Vinogradova, I.A. Biochim. Biophys. Acta (2006) [Pubmed]
 
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