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Gene Review

lgs  -  legless

Drosophila melanogaster

Synonyms: BCL9, CG2041, Dm Lgs, Dmel\CG2041, Lgl, ...
 
 
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Disease relevance of lgs

 

High impact information on lgs

  • Genetic and biochemical experiments show that Lgl phosphorylation prevents the localization of cell fate determinants to the apical cell cortex [2].
  • The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl [2].
  • Notably, linking Armadillo to a nuclear localization sequence rescues pygo and lgs mutant fly embryos [3].
  • The molecular mechanisms by which Dlg, Scrib and Lgl proteins regulate cell proliferation are not clear, but there is some evidence that epithelial polarisation is required for this regulation [4].
  • In Drosophila, another set of proteins called tumor suppressors, such as Lgl, which localize separately to the basolateral membrane domain but genetically interact with the subapical proteins, also contribute to the establishment of cell polarity [5].
 

Biological context of lgs

 

Anatomical context of lgs

References

  1. Identification and characterization of human BCL9L gene and mouse Bcl9l gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]
  2. The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Betschinger, J., Mechtler, K., Knoblich, J.A. Nature (2003) [Pubmed]
  3. Pygopus and Legless target Armadillo/beta-catenin to the nucleus to enable its transcriptional co-activator function. Townsley, F.M., Cliffe, A., Bienz, M. Nat. Cell Biol. (2004) [Pubmed]
  4. Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Humbert, P., Russell, S., Richardson, H. Bioessays (2003) [Pubmed]
  5. Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity. Yamanaka, T., Horikoshi, Y., Sugiyama, Y., Ishiyama, C., Suzuki, A., Hirose, T., Iwamatsu, A., Shinohara, A., Ohno, S. Curr. Biol. (2003) [Pubmed]
  6. Developmental genetics of loci at the base of the X chromosome of Drosophila melanogaster. Perrimon, N., Smouse, D., Miklos, G.L. Genetics (1989) [Pubmed]
  7. Regulation of Lethal giant larvae by Dishevelled. Dollar, G.L., Weber, U., Mlodzik, M., Sokol, S.Y. Nature (2005) [Pubmed]
  8. Identification and characterization of rat Bcl9l gene in silico. Katoh, Y., Katoh, M. Int. J. Oncol. (2005) [Pubmed]
 
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