High impact information on Ppn

• We suggest that papilin influences cell rearrangements and may modulate metalloproteinases during organogenesis [1].
• Ectopic expression of papilin in Drosophila causes lethal abnormalities in muscle, Malpighian tubule and trachea formation [1].
• Papilin: a Drosophila proteoglycan-like sulfated glycoprotein from basement membranes [2].
• The buoyant density of papilin in CsCl/4 M guanidine hydrochloride is 1.4 g/ml, that of the core protein is much less [2].
• Alternative splicing of papilin and the diversity of Drosophila extracellular matrix during embryonic morphogenesis [3].

Biological context of Ppn

• We report that Drosophila, which has a compact genome, expresses three splice variants of papilin during embryogenesis in developmentally defined patterns [3].

Associations of Ppn with chemical compounds

• A sulfated glycoprotein was isolated from the culture media of Drosophila Kc cells and named papilin [2].

Analytical, diagnostic and therapeutic context of Ppn

• Papilin forms oligomers linked by disulfide bridges, as shown by sodium dodecyl sulfate-agarose gel electrophoresis and electron microscopy [2].

References