Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

MRX27 - mental retardation, X-linked 27

Homo sapiens

Lower, K.M. et al., Gécz, J. et al., Gedeon, A.K. et al.

Gécz, Barnett, Liu, Hollway, Donnelly, Eyre, Eshkevari, Baltazar, Grunn, Nagaraja, Gilliam, Peltonen, Sutherland, Baron, Mulley, Lower, Gecz,

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Disease relevance of MRX27

No mutations were detected in families segregating disorders mapping across GRIA3, one with X-linked bipolar affective disorder (BP) and one with a nonspecific X-linked mental retardation (MRX27) [1].

Psychiatry related information on MRX27

A nonsyndromic mental retardation family, MRX27, has also been localized to a region of the X chromosome overlapping Xq26-q27 [2].

High impact information on MRX27

Although ARHGEF6 is unlikely to be the gene responsible for either BFLS or MRX27, it remains a prime candidate for nonspecific or syndromic mental retardation linked to Xq26 [2].
No mutations were found in two BFLS families or MRX27 [2].
Genetic localisation of MRX27 to Xq24-26 defines another discrete gene for non-specific X-linked mental retardation [3].

References

Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation. Gécz, J., Barnett, S., Liu, J., Hollway, G., Donnelly, A., Eyre, H., Eshkevari, H.S., Baltazar, R., Grunn, A., Nagaraja, R., Gilliam, C., Peltonen, L., Sutherland, G.R., Baron, M., Mulley, J.C. Genomics (1999) [Pubmed]
Characterization of ARHGEF6, a guanine nucleotide exchange factor for Rho GTPases and a candidate gene for X-linked mental retardation: mutation screening in Börjeson-Forssman-Lehmann syndrome and MRX27. Lower, K.M., Gecz, J. Am. J. Med. Genet. (2001) [Pubmed]
Genetic localisation of MRX27 to Xq24-26 defines another discrete gene for non-specific X-linked mental retardation. Gedeon, A.K., Glass, I.A., Connor, J.M., Mulley, J.C. Am. J. Med. Genet. (1996) [Pubmed]

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