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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Spt6  -  CG12225 gene product from transcript...

Drosophila melanogaster

Synonyms: CG12225, Dmel\CG12225, Dspt6, SPT6, Transcription elongation factor SPT6, ...
 
 
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High impact information on Spt6

  • High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation [1].
  • For a model system, we used this technology to confirm the X chromosomal mapping of Dspt6 given the autosomal mapping of Dspt4 [2].
 

Biological context of Spt6

  • Here, we show that Drosophila Spt5 and Spt6 colocalize at a large number of transcriptionally active chromosomal sites on polytene chromosomes and are rapidly recruited to endogenous and transgenic heat shock loci upon heat shock [1].

References

  1. High-resolution localization of Drosophila Spt5 and Spt6 at heat shock genes in vivo: roles in promoter proximal pausing and transcription elongation. Andrulis, E.D., Guzmán, E., Döring, P., Werner, J., Lis, J.T. Genes Dev. (2000) [Pubmed]
  2. A fluorescent quantitative PCR approach to map gene deletions in the Drosophila genome. Chiang, P.W., Wei, W.L., Gibson, K., Bodmer, R., Kurnit, D.M. Genetics (1999) [Pubmed]
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