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Gene Review

Hex-C  -  Hexokinase C

Drosophila melanogaster

Synonyms: CG8094, CT22069, DM2, Dmel\CG8094, Fk, ...
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Disease relevance of Hex-C


High impact information on Hex-C

  • Three band-morph mutants, one at the Mdh locus, one at the Hex-C locus, and one at the Amy locus, were detected out of 1,658,308 allele replications [2].
  • Antisera against purified Hex A and Hex C were raised in rabbits [3].
  • In D. melanogaster latitudinal clines are seen for amino acid polymorphisms at the Hex-C and Hex-t2 loci [4].
  • As part of a larger study contrasting patterns of variation in regulatory and nonregulatory enzymes of the central metabolic pathways we have examined the molecular variation in four uncharacterized hexokinase genes unique to muscle, fat body, and testis in Drosophila melanogaster, D. simulans, and D. yakuba [4].
  • Exposure to benzaldehyde at days 2-5 of adult life, but not at 8-11, causes behavioral adaptation as well as structural changes in DM2 and V glomeruli [5].

Biological context of Hex-C

  • Amino acid sequence alignment of DM1 and DM2 shows approximately 45% homology with yeast and human hexokinases [6].
  • Southern blot analysis suggests that the D. melanogaster genome contain a single copy of DM1 and DM2 sequences [6].
  • Such sexually mosaic flies courted not only females but also males when the DM2, DA3 and DA4 glomeruli were feminized, indicating that these substructures in the antennal lobe may be involved in the determination of the sexual orientation of flies [7].

Anatomical context of Hex-C


Associations of Hex-C with chemical compounds


Analytical, diagnostic and therapeutic context of Hex-C


  1. Muscleblind localizes to nuclear foci of aberrant RNA in myotonic dystrophy types 1 and 2. Mankodi, A., Urbinati, C.R., Yuan, Q.P., Moxley, R.T., Sansone, V., Krym, M., Henderson, D., Schalling, M., Swanson, M.S., Thornton, C.A. Hum. Mol. Genet. (2001) [Pubmed]
  2. Spontaneous mutation rates at enzyme loci in Drosophila melanogaster. Mukai, T., Cockerham, C.C. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  3. Multiple forms of Drosophila hexokinase. Purification, biochemical and immunological characterization. Moser, D., Johnson, L., Lee, C.Y. J. Biol. Chem. (1980) [Pubmed]
  4. Contrasting molecular population genetics of four hexokinases in Drosophila melanogaster, D. simulans and D. yakuba. Duvernell, D.D., Eanes, W.F. Genetics (2000) [Pubmed]
  5. Structural and functional changes in the olfactory pathway of adult Drosophila take place at a critical age. Devaud, J.M., Acebes, A., Ramaswami, M., Ferrús, A. J. Neurobiol. (2003) [Pubmed]
  6. Cloning of two hexokinase isoenzyme sequences from Drosophila melanogaster. Jayakumar, P.C., Shouche, Y.S., Patole, M.S. Insect Biochem. Mol. Biol. (2001) [Pubmed]
  7. Genetic dissection of sexual orientation: behavioral, cellular, and molecular approaches in Drosophila melanogaster. Yamamoto, D., Ito, H., Fujitani, K. Neurosci. Res. (1996) [Pubmed]
  8. A novel adenosine triphosphate analog with a heavy atom to target the nucleotide binding site of proteins. Naber, N., Matuska, M., Sablin, E.P., Pate, E., Cooke, R. Protein Sci. (1995) [Pubmed]
  9. Mechanism of mannose toxicity. de la Fuente, M., Peñas, P.F., Sols, A. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
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