Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PLEK - pleckstrin

Canis lupus familiaris

Yamaga, M. et al., Paterson, H.F. et al., Hirose, K. et al.

Hirose, Kadowaki, Tanabe, Takeshima, Iino,

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High impact information on PLEK

In Madin-Darby canine kidney epithelial cells, green fluorescent protein-tagged pleckstrin homology domain translocated from the plasma membrane to the cytoplasm in response to increased concentration of IP3 [1].
A site-directed mutant containing a pleckstrin homology domain, which does not bind inositol 1,4,5-trisphosphate and cannot hydrolyze phosphatidylinositol 4,5-bisphosphate in vitro, accumulated in the nucleus to a much greater extent than wild-type GFP/PLC-delta1 after treatment with leptomycin B [2].
Microinjection of deletion mutants revealed that the region required for membrane attachment and binding of inositol 1,4,5-trisphosphate in vitro corresponded to the pleckstrin homology domain, a structural module described in more than 90 proteins [3].

References

Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns. Hirose, K., Kadowaki, S., Tanabe, M., Takeshima, H., Iino, M. Science (1999) [Pubmed]
Phospholipase C-delta1 contains a functional nuclear export signal sequence. Yamaga, M., Fujii, M., Kamata, H., Hirata, H., Yagisawa, H. J. Biol. Chem. (1999) [Pubmed]
Phospholipase C delta 1 requires a pleckstrin homology domain for interaction with the plasma membrane. Paterson, H.F., Savopoulos, J.W., Perisic, O., Cheung, R., Ellis, M.V., Williams, R.L., Katan, M. Biochem. J. (1995) [Pubmed]

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PLEK	Bos taurus
plek	Danio rerio
PLEK	Gallus gallus
PLEK	Homo sapiens
PLEK	Macaca mulatta
Plek	Mus musculus
PLEK	Pan troglodytes
Plek	Rattus norvegicus
plek	Xenopus (Silurana) tropicalis

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