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Gene Review

LOC442975  -  mucin

Canis lupus familiaris

 
 
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Disease relevance of LOC442975

 

High impact information on LOC442975

 

Chemical compound and disease context of LOC442975

 

Biological context of LOC442975

  • Methylation analysis of product formed either with mucin acceptor or Gal beta 1-3GalNAc-alpha-O-benzyl indicated GlcNAc transfer to either carbon 4 or carbon 6 of the GalNAc residue of the acceptors [10].
  • Alignment of the amino acid sequences inferred from the cDNA nucleotide sequences showed that BS-C-1 and CV-1 havcr-1 differed from GL37 havcr-1 by having two substitutions in the Cys-rich region, N48H and K108Q, and 10 to 11 additional substitutions plus the insertion of 18 to 22 amino acids in the mucin-like region [11].
  • We investigated how different patterns of [Ca(2+)](i) signals evoke salt secretion via ion transport mechanisms and mucin secretion via exocytosis in dog pancreatic duct epithelial cells (PDEC) [12].
  • However, no effect of the presumed altered membrane fluidity on TUDC (10 mM)-induced mucin secretion was observed [13].
  • In the present study we have investigated whether established second messenger pathways are involved in bile salt-induced mucin secretion [14].
 

Anatomical context of LOC442975

  • The synthesis and release of mucin and phospholipid are functions of the mucous cell that play a critical role in the primary defense of gastric epithelium [3].
  • Using immunocytochemical and biochemical techniques, mucin synthesis and secretion were confirmed by these cell lines [3].
  • During absorption, NNK was distributed within the entire depth of the mucosa to the tracheal cartilage; however, a portion was conspicuously bound to the mucin component of the mucous lining layer [15].
  • Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc leads to GalNAc) beta 6-N-acetylglucosaminyltransferase [16].
  • This protein, gp40, was characterized as an O-glycosylated (mucin-type) integral membrane protein of 40 kDa, which was predominantly localized on the apical plasma membrane of filter-grown cells [17].
 

Associations of LOC442975 with chemical compounds

  • Aspirin given to prairie dogs inhibited mucin hypersecretion and gel accumulation and prevented gallstone formation without influencing the cholesterol content of supersaturated bile [1].
  • Purified mucin in the concentration of 0.5-2 mg/mL of glycoprotein led to a significant dose-dependent increase in phospholipid solubility, suggesting the formation of a glycoprotein-phospholipid complex [3].
  • Furthermore, incubation of explants with 10(-5) mol/L indomethacin failed to prevent in vitro mucin hypersecretion in cholesterol-fed animals [2].
  • Some studies have suggested that gallbladder mucin hypersecretion is mediated by increases in gallbladder prostaglandin synthesis, but other observations are difficult to reconcile with this view [2].
  • Taurocholate caused a dose-dependent increase in mucin secretion, suggesting that bile salt was the bile component responsible for the stimulatory effect [7].
 

Other interactions of LOC442975

  • The MUC1 gene product (PEM, polymorphic epithelial mucin) is a cell-associated glycoprotein expressed on the apical surface of most simple secretory epithelia [18].
  • Exogenous tumor necrosis factor alpha (TNF-alpha) (1-10 ng/mL) did cause a minor increase in mucin secretion by the DGBE cells, but the effect of LPS from E. coli on mucin secretion could not be inhibited by preincubation with a TNF-alpha antibody (10 microg/mL) [4].
  • In conclusion, our results suggested that the PGE2 induced by COX-2 might play a role in mucin secretion from the gallbladder epithelium through the increment of cAMP [19].
  • Mucin assay and western blots for COX-1 and COX-2 were performed [19].
  • Correlations were made after parenteral injection of secretin which increased movement of tantalum particles and production of mucin, and after injection of glucagon, which stopped movement of the particles and decreased mucin secretion in the pouch [20].
 

Analytical, diagnostic and therapeutic context of LOC442975

  • An organ culture technique was used to measure mucin secretion in normal prairie dog gallbladder in response to exogenous prostaglandins and agents that increased or decreased endogenous prostaglandin production [2].
  • A 7.8% +/- 1.7% increase in mucin above basal levels after 24 hours was observed with a solid-phase immunoassay in control wells, whereas histamine, gastrin, and carbamylcholine increased total mucin by 14% +/- 0.7%, 17% +/- 4.3%, and 20.4% +/- 4%, respectively (all P < 0.01), and PGE2 had no significant effect [8].
  • In the present study, mucin production and release of the surface-active phospholipid phosphatidylcholine (PC) into the medium were measured with an isolated canine mucous cell culture system [8].
  • We have examined the trafficking of the mucin-like protein endolyn in transfected, polarized MDCK cells using biochemical approaches and immunofluorescence microscopy [21].
  • The translation products were analyzed by gel electrophoresis and fluorography before and after immunoprecipitation with the antiserum to deglycosylated mucin [22].

References

  1. Aspirin prevention of cholesterol gallstone formation in prairie dogs. Lee, S.P., Carey, M.C., LaMont, J.T. Science (1981) [Pubmed]
  2. Inhibition of prostaglandin synthesis fails to prevent gallbladder mucin hypersecretion in the cholesterol-fed prairie dog. O'Leary, D.P., LaMorte, W.W., Scott, T.E., Booker, M.L., Stevenson, J. Gastroenterology (1991) [Pubmed]
  3. Synthesis and prostaglandin E2-induced secretion of surfactant phospholipid by isolated gastric mucous cells. Scheiman, J.M., Kraus, E.R., Bonnville, L.A., Weinhold, P.A., Boland, C.R. Gastroenterology (1991) [Pubmed]
  4. Lipopolysaccharide from Escherichia coli stimulates mucin secretion by cultured dog gallbladder epithelial cells. Choi, J., Klinkspoor, J.H., Yoshida, T., Lee, S.P. Hepatology (1999) [Pubmed]
  5. Effect of cyclosporine on conjunctival mucin in a canine keratoconjunctivitis sicca model. Moore, C.P., McHugh, J.B., Thorne, J.G., Phillips, T.E. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  6. Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells. Longphre, M., Li, D., Gallup, M., Drori, E., Ordoñez, C.L., Redman, T., Wenzel, S., Bice, D.E., Fahy, J.V., Basbaum, C. J. Clin. Invest. (1999) [Pubmed]
  7. Model bile and bile salts accelerate mucin secretion by cultured dog gallbladder epithelial cells. Klinkspoor, J.H., Kuver, R., Savard, C.E., Oda, D., Azzouz, H., Tytgat, G.N., Groen, A.K., Lee, S.P. Gastroenterology (1995) [Pubmed]
  8. Regulation of canine gastric mucin synthesis and phospholipid secretion by acid secretagogues. Scheiman, J.M., Kraus, E.R., Boland, C.R. Gastroenterology (1992) [Pubmed]
  9. The effect of secretin on colonic mucin secretion rate in the dog. Hattner, R.S., Margulis, A.R., Skioldebrand, K.C., Hartmeyer, J., Stoughton, J. European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes. (1984) [Pubmed]
  10. Mucin synthesis. I. Detection in canine submaxillary glands of an N-acetylglucosaminyltransferase which acts on mucin substrates. Williams, D., Schachter, H. J. Biol. Chem. (1980) [Pubmed]
  11. Polymorphisms of the hepatitis A virus cellular receptor 1 in African green monkey kidney cells result in antigenic variants that do not react with protective monoclonal antibody 190/4. Feigelstock, D., Thompson, P., Mattoo, P., Kaplan, G.G. J. Virol. (1998) [Pubmed]
  12. Pattern of Ca2+ increase determines the type of secretory mechanism activated in dog pancreatic duct epithelial cells. Jung, S.R., Kim, K., Hille, B., Nguyen, T.D., Koh, D.S. J. Physiol. (Lond.) (2006) [Pubmed]
  13. Bile salts stimulate mucin secretion by cultured dog gallbladder epithelial cells independent of their detergent effect. Klinkspoor, J.H., Yoshida, T., Lee, S.P. Biochem. J. (1998) [Pubmed]
  14. Mechanism of bile salt-induced mucin secretion by cultured dog gallbladder epithelial cells. Klinkspoor, J.H., Tytgat, G.N., Lee, S.P., Groen, A.K. Biochem. J. (1996) [Pubmed]
  15. A relevant dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is extensively metabolized and rapidly absorbed in the canine tracheal mucosa. Gerde, P., Muggenburg, B.A., Stephens, T., Lewis, J.L., Pyon, K.H., Dahl, A.R. Cancer Res. (1998) [Pubmed]
  16. Mucin synthesis. II. Substrate specificity and product identification studies on canine submaxillary gland UDP-GlcNAc:Gal beta 1-3GalNAc(GlcNAc leads to GalNAc) beta 6-N-acetylglucosaminyltransferase. Williams, D., Longmore, G., Matta, K.L., Schachter, H. J. Biol. Chem. (1980) [Pubmed]
  17. Identification of a 40-kDa cell surface sialoglycoprotein with the characteristics of a major influenza C virus receptor in a Madin-Darby canine kidney cell line. Zimmer, G., Klenk, H.D., Herrler, G. J. Biol. Chem. (1995) [Pubmed]
  18. The epithelial mucin MUC1 contains at least two discrete signals specifying membrane localization in cells. Pemberton, L.F., Rughetti, A., Taylor-Papadimitriou, J., Gendler, S.J. J. Biol. Chem. (1996) [Pubmed]
  19. Cyclooxygenase-2 mediates mucin secretion from epithelial cells of lipopolysaccharide-treated canine gallbladder. Kim, H.J., Lee, S.K., Kim, M.H., Seo, D.W., Min, Y.I. Dig. Dis. Sci. (2003) [Pubmed]
  20. Colonic mucin secretion related to non-contractile motility in the dog. Skiöldebrand, C.G., Margulis, A.R., Hattner, R.S., Hartmeyer, J., Stoughton, J.A. Acta radiologica: diagnosis. (1981) [Pubmed]
  21. Competing sorting signals guide endolyn along a novel route to lysosomes in MDCK cells. Ihrke, G., Bruns, J.R., Luzio, J.P., Weisz, O.A. EMBO J. (2001) [Pubmed]
  22. Translation of messenger RNA from canine tracheal epithelial cells: identification of mucin core protein. Virmani, A.K., Shankar, V., Gilmore, M.S., Graves, D.C., Sachdev, G.P. Am. J. Respir. Cell Mol. Biol. (1991) [Pubmed]
 
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