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Gene Review

LOC443015  -  beta-tubulin

Ovis aries

 
 
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Disease relevance of LOC443015

  • Here we report evidence that ivermectin selection changes the frequency of beta-tubulin alleles in both the sheep parasite, H. contortus, and the human parasite, O. volvulus [1].
 

High impact information on LOC443015

  • Moreover, using a tubulin recombinant alpha-tubulin C-terminal fragment (404-451) and a beta-tubulin C-terminal fragment (394-445), we demonstrated the involvement of both of these tubulin regions in tau binding [2].
  • The specificity of this effect was confirmed by showing no decrease in either beta-tubulin or neomycin phosphotransferase mRNA levels [3].
  • Ivermectin selection on beta-tubulin: Evidence in Onchocerca volvulus and Haemonchus contortus [1].
  • The resistance of gastro-intestinal nematodes of small ruminants (sheep and goat) to benzimidazole anthelmintic drugs seems to be linked primarily to a single mutation in the isotype 1 beta-tubulin gene [4].
  • A large part of the gamma-tubulin was present in cold stable material remaining after microtubule disassembly at OdegreesC and was partially solubilized using high salt, thus preventing its purification by the usual assembly/disassembly procedure used for alpha/beta-tubulin heterodimers [5].
 

Biological context of LOC443015

 

Anatomical context of LOC443015

  • These results implicate type 1 beta-tubulin in mediating apical vesicle transport in intestinal cells and suggest that the tyr200 variant is a determinant of FBZ resistance in intestinal cells [10].
 

Associations of LOC443015 with chemical compounds

 

Other interactions of LOC443015

  • This distinctiveness was corroborated by sequences of the beta-tubulin isotype I gene, the second internal transcribed spacer (ITS2) of their rDNA, and the nicotinamide dehydrogenase (ND4) gene of their mDNA [14].
 

Analytical, diagnostic and therapeutic context of LOC443015

  • We report a simple PCR assay to detect the amplicon length polymorphism, resulting from these intronic deletions, which can be used to monitor the frequency of the beta-tubulin allele selected for by ivermectin in O. volvulus [1].

References

  1. Ivermectin selection on beta-tubulin: Evidence in Onchocerca volvulus and Haemonchus contortus. Eng, J.K., Blackhall, W.J., Osei-Atweneboana, M.Y., Bourguinat, C., Galazzo, D., Beech, R.N., Unnasch, T.R., Awadzi, K., Lubega, G.W., Prichard, R.K. Mol. Biochem. Parasitol. (2006) [Pubmed]
  2. Tau induces ring and microtubule formation from alphabeta-tubulin dimers under nonassembly conditions. Devred, F., Barbier, P., Douillard, S., Monasterio, O., Andreu, J.M., Peyrot, V. Biochemistry (2004) [Pubmed]
  3. Inducible anti-sense RNA for angiotensinogen in stably transformed hepatoma cell lines. Clouston, W.M., Lloyd, C.J., Richards, R.I. J. Mol. Endocrinol. (1990) [Pubmed]
  4. Diversity of benzimidazole-resistance alleles in populations of small ruminant parasites. Silvestre, A., Humbert, J.F. Int. J. Parasitol. (2002) [Pubmed]
  5. Protein complexes containing gamma-tubulin are present in mammalian brain microtubule protein preparations. Detraves, C., Mazarguil, H., Lajoie-Mazenc, I., Julian, M., Raynaud-Messina, B., Wright, M. Cell Motil. Cytoskeleton (1997) [Pubmed]
  6. Species-specific PCR for the parasitic nematodes Haemonchus contortus and Trichostrongylus colubriformis. Roos, M.H., Grant, W.N. Int. J. Parasitol. (1993) [Pubmed]
  7. Effect of selection for benzimidazole resistance in Haemonchus contortus on beta-tubulin isotype 1 and isotype 2 genes. Kwa, M.S., Kooyman, F.N., Boersema, J.H., Roos, M.H. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  8. Bundling of microtubules by synapsin 1. Characterization of bundling and interaction of distinct sites in synapsin 1 head and tail domains with different sites in tubulin. Bennett, A.F., Baines, A.J. Eur. J. Biochem. (1992) [Pubmed]
  9. Importance of the mutation of amino acid 200 of the isotype 1 beta-tubulin gene in the benzimidazole resistance of the small-ruminant parasite Teladorsagia circumcincta. Elard, L., Humbert, J.F. Parasitol. Res. (1999) [Pubmed]
  10. Distinct characteristics of two intestinal protein compartments discriminated by using fenbendazole and a benzimidazole resistant isolate of Haemonchus contortus. Shompole, S., Yao, C., Cheng, X., Knox, D., Johnson, S., Jasmer, D.P. Exp. Parasitol. (2002) [Pubmed]
  11. Influence of the composition of commercial sodium dodecyl sulfate preparations on the separation of alpha- and beta-tubulin during polyacrylamide gel electrophoresis. Best, D., Warr, P.J., Gull, K. Anal. Biochem. (1981) [Pubmed]
  12. PCR diagnosis of benzimidazole-susceptibility or -resistance in natural populations of the small ruminant parasite, Teladorsagia circumcincta. Elard, L., Cabaret, J., Humbert, J.F. Vet. Parasitol. (1999) [Pubmed]
  13. Enantioselective binding of albendazole sulphoxide to cytosolic proteins from helminth parasites. Solana, H.D., Sallovitz, J.M., Lanusse, C.E., Rodriguez, J.A. Methods and findings in experimental and clinical pharmacology. (2002) [Pubmed]
  14. New molecular evidence that Teladorsagia circumcincta (Nematoda: Trichostrongylidea) is a species complex. Leignel, V., Cabaret, J., Humbert, J.F. J. Parasitol. (2002) [Pubmed]
 
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