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Gene Review:

LOC443144 - mineralocorticoid receptor

Ovis aries

Synonyms: MLR, NR3C2

Roesch, D.M. et al., Keller-Wood, M. et al., Gomez-Sanchez, E.P. et al.

Keller-Wood, Wood, Hua, Zhang,

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High impact information on LOC443144

Other samples of fetal lungs were fixed for localization of MR and Na+, K+ adenosine triphosphatase (ATPase) alpha by immunohistochemistry [1].
Immunoreactive MR was found in pulmonary epithelial cells and to be colocalized with Na+, K+ ATPase alpha in many sites [1].
MR mRNA was identified in lung tissue from fetuses and newborn lambs, but not from pregnant ewes; MR-regulated genes, including SGK1 and ENaCalpha were also expressed in fetal and newborn lungs [1].
MR availability significantly increased from undetectable levels in hippocampal cytosols obtained from nonpregnant ewes to 2.8 +/- 1.6 fmol/mg protein in pregnant ewes, suggesting a reduced MR activation in the hippocampus during pregnancy [2].
We hypothesize that an alteration in activation and/or autoregulation of the MR during pregnancy, particularly in the hippocampus, may contribute to the observed changes in receptor availability and immunoreactivity and increase basal plasma cortisol levels during pregnancy [2].

Other interactions of LOC443144

The 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) enzymes convert corticosterone and cortisol to 11-dehydrocorticosterone and cortisone, and are thought to convey extrinsic specificity to the mineralocorticoid receptor by limiting access of the relatively more abundant glucocorticoids to it [3].

References

Mineralocorticoid receptor expression in late-gestation ovine fetal lung. Keller-Wood, M., Wood, C.E., Hua, Y., Zhang, D. J. Soc. Gynecol. Investig. (2005) [Pubmed]
Differential effects of pregnancy on mineralocorticoid and glucocorticoid receptor availability and immunoreactivity in cortisol feedback sites. Roesch, D.M., Keller-Wood, M. Neuroendocrinology (1999) [Pubmed]
The sheep kidney contains a novel unidirectional, high affinity NADP(+)-dependent 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD-3). Gomez-Sanchez, E.P., Ganjam, V., Chen, Y.J., Cox, D.L., Zhou, M.Y., Thanigaraj, S., Gomez-Sanchez, C.E. Steroids (1997) [Pubmed]

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