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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

SLC11A1  -  solute carrier family 11 (proton-coupled...

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Disease relevance of NRAMP1

 

High impact information on NRAMP1

  • These findings suggest that bacterial infection and proinflammatory mediators induce NRAMP1 expression via activation of MAPK pathways [2].
  • Cloning of porcine NRAMP1 and its induction by lipopolysaccharide, tumor necrosis factor alpha, and interleukin-1beta: role of CD14 and mitogen-activated protein kinases [2].
  • Investigation of the molecular mechanisms by which NRAMP1 is induced showed that LPS-induced expression in macrophages, neutrophils, and peripheral blood mononuclear cells was time and dose dependent and was mediated primarily through CD14 [2].
  • Here, we report the cloning of the full-length cDNA for porcine NRAMP1, which had over 85% identity in amino acid sequence to its congeners from humans, mice, cattle, and sheep [2].
  • Although its functions remain unclear, recent clues suggest that NRAMP1 protein plays a potential role in ion transport, which presumably accounts for the ability of this single protein to regulate the intraphagosomal replication of several species of antigenically unrelated intracellular pathogens [2].
 

Biological context of NRAMP1

  • To study in sheep the influence of the NRAMP1 gene on the susceptibility to intracellular pathogens induced diseases, we have cloned the sheep NRAMP1 cDNA by screening a splenic cDNA library [1].
  • Two polymorphic microsatellite markers close to the ovine NRAMP gene [4].
  • Here we test for evidence of selection in three genes involved in vertebrate immune function - the major histocompatibility complex (MHC), interferon gamma (IFNG) and natural resistance associated macrophage polymorphism (NRAMP) - in highly structured populations of wild thinhorn sheep (Ovis dalli) [5].
  • Correlations with phenotype were sought for polymorphisms at loci within selected immune function genes (NRAMP, MHC complex, IFN-gamma, lysozyme, leukaemia inhibiting factor) [3].
 

Anatomical context of NRAMP1

  • The ovine NRAMP1 and cervine NRAMP1 cDNAs were cloned by RT PCR of RNA derived from macrophage enriched leukocyte preparations [6].
  • As for its mammalian congeners, expression of porcine NRAMP1 mRNA was cell and tissue specific and was highest in macrophages [2].
 

Other interactions of NRAMP1

 

Analytical, diagnostic and therapeutic context of NRAMP1

References

  1. cDNA cloning, structural organization, and expression of the sheep NRAMP1 gene. Bussmann, V., Lantier, I., Pitel, F., Patri, S., Nau, F., Gros, P., Elsen, J.M., Lantier, F. Mamm. Genome (1998) [Pubmed]
  2. Cloning of porcine NRAMP1 and its induction by lipopolysaccharide, tumor necrosis factor alpha, and interleukin-1beta: role of CD14 and mitogen-activated protein kinases. Zhang, G., Wu, H., Ross, C.R., Minton, J.E., Blecha, F. Infect. Immun. (2000) [Pubmed]
  3. A preliminary study of possible genetic influences on the susceptibility of sheep to Johne's disease. Reddacliff, L.A., Beh, K., McGregor, H., Whittington, R.J. Aust. Vet. J. (2005) [Pubmed]
  4. Two polymorphic microsatellite markers close to the ovine NRAMP gene. Pitel, F., Lantier, I., Gellin, J., Elsen, J.M., Lantier, F. Anim. Genet. (1996) [Pubmed]
  5. Detecting the signature of selection on immune genes in highly structured populations of wild sheep (Ovis dalli). Worley, K., Carey, J., Veitch, A., Coltman, D.W. Mol. Ecol. (2006) [Pubmed]
  6. Cloning, sequencing and linkage mapping of the NRAMP1 gene of sheep and deer. Matthews, G.D., Crawford, A.M. Anim. Genet. (1998) [Pubmed]
 
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