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Gene Review:

HSD11B1 - hydroxysteroid (11-beta) dehydrogenase 1

Ovis aries

Yang, K. et al., Yang, K. et al., Touitou, Y. et al., Yang, K. et al., Gomez-Sanchez, E.P. et al., et al.

Yang, Fraser, Yu, Krkosek, Challis, Lamming, Campbell, Darnel,

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Disease relevance of HSD11B1

OBJECTIVE: To examine the effect of sustained hypoxia on the expression of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) type 1 and 2 genes in preterm fetal sheep [1].
Effects of hypoxemia on 11 beta-hydroxysteroid dehydrogenase types 1 and 2 gene expression in preterm fetal sheep [1].

High impact information on HSD11B1

In fact, since most of the studied indoles reduced 11 beta-hydroxysteroid dehydrogenase activity, the actual activation of cortisol synthesis was four to five times less [2].
This work demonstrates the activating effect of some indole compounds on 11 beta-hydroxylase and 17,20-desmolase and the inhibitory effect of most of them on 11 beta-hydroxysteroid dehydrogenase [2].
The 11 beta-hydroxysteroid dehydrogenase (11-beta HSD) inhibitor carbenoxolone did not change the effect of cortisol in nonpregnant UA but abolished its effect in pregnant UA by increasing the NE pD(2) in control tissues from 6.20 +/- 0.05 to 6.59 +/- 0.11 [3].
Pattern of 11 beta-hydroxysteroid dehydrogenase type 1 messenger ribonucleic acid expression in the ovine uterus during the estrous cycle and pregnancy [4].
The present study was designed to examine the pattern and cellular localization of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) gene expression in the ovine uterus during pregnancy and at 3 mo postpartum [4].

Biological context of HSD11B1

Developmental and glucocorticoid regulation of pituitary 11 beta-hydroxysteroid dehydrogenase 1 gene expression in the ovine fetus and lamb [5].
Identification and tissue distribution of a novel variant of 11 beta-hydroxysteroid dehydrogenase 1 transcript [6].
Alterations in placental 11 beta-hydroxysteroid dehydrogenase (11 betaHSD) activities and fetal cortisol:cortisone ratios induced by nutritional restriction prior to conception and at defined stages of gestation in ewes [7].

Anatomical context of HSD11B1

Cellular localization of 11 beta-hydroxysteroid dehydrogenase 2 gene expression in the ovine adrenal gland [8].
Expression of genes encoding pro-opiomelanocortin (POMC), glucocorticoid receptors and 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) was studied in sheep fetuses during development [9].

Other interactions of HSD11B1

The 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) enzymes convert corticosterone and cortisol to 11-dehydrocorticosterone and cortisone, and are thought to convey extrinsic specificity to the mineralocorticoid receptor by limiting access of the relatively more abundant glucocorticoids to it [10].

Analytical, diagnostic and therapeutic context of HSD11B1

To examine the role of 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1) in the control of glucocorticoid actions in the ovine pituitary during development, we have sought developmental changes in the distribution and the level of 11 beta-HSD1 mRNA by in situ hybridization [5].
A novel variant of 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1) mRNA was identified from the ovine liver by reverse transcription-polymerase chain reaction (RT/PCR), and was named 11 beta-HSD1C mRNA [6].

References

Effects of hypoxemia on 11 beta-hydroxysteroid dehydrogenase types 1 and 2 gene expression in preterm fetal sheep. Yang, K., Shearman, K., Asano, H., Richardson, B.S. J. Soc. Gynecol. Investig. (1997) [Pubmed]
Activity of melatonin and other pineal indoles on the in vitro synthesis of cortisol, cortisone, and adrenal androgens. Touitou, Y., Bogdan, A., Auzéby, A., Touitou, C. J. Pineal Res. (1989) [Pubmed]
Cortisol-mediated potentiation of uterine artery contractility: effect of pregnancy. Xiao, D., Huang, X., Bae, S., Ducsay, C.A., Zhang, L. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
Pattern of 11 beta-hydroxysteroid dehydrogenase type 1 messenger ribonucleic acid expression in the ovine uterus during the estrous cycle and pregnancy. Yang, K., Fraser, M., Yu, M., Krkosek, M., Challis, J.R., Lamming, G.E., Campbell, L.E., Darnel, A. Biol. Reprod. (1996) [Pubmed]
Developmental and glucocorticoid regulation of pituitary 11 beta-hydroxysteroid dehydrogenase 1 gene expression in the ovine fetus and lamb. Yang, K., Matthews, S.G., Challis, J.R. J. Mol. Endocrinol. (1995) [Pubmed]
Identification and tissue distribution of a novel variant of 11 beta-hydroxysteroid dehydrogenase 1 transcript. Yang, K., Yu, M., Han, V.K. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
Alterations in placental 11 beta-hydroxysteroid dehydrogenase (11 betaHSD) activities and fetal cortisol:cortisone ratios induced by nutritional restriction prior to conception and at defined stages of gestation in ewes. McMullen, S., Osgerby, J.C., Thurston, L.M., Gadd, T.S., Wood, P.J., Wathes, D.C., Michael, A.E. Reproduction (2004) [Pubmed]
Cellular localization of 11 beta-hydroxysteroid dehydrogenase 2 gene expression in the ovine adrenal gland. Yang, K., Matthews, S.G. Mol. Cell. Endocrinol. (1995) [Pubmed]
Regulation of gene expression in the ovine fetus. Yang, K. J. Reprod. Fertil. Suppl. (1992) [Pubmed]
The sheep kidney contains a novel unidirectional, high affinity NADP(+)-dependent 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD-3). Gomez-Sanchez, E.P., Ganjam, V., Chen, Y.J., Cox, D.L., Zhou, M.Y., Thanigaraj, S., Gomez-Sanchez, C.E. Steroids (1997) [Pubmed]

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