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drl  -  derailed

Drosophila melanogaster

Synonyms: CG10758, CG17348, DRL, Dmel\CG17348, Drl, ...
 
 
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Psychiatry related information on drl

 

High impact information on drl

  • Commissure choice is controlled by Derailed, an atypical receptor tyrosine kinase expressed on axons projecting in the anterior commissure [2].
  • Using a newly developed axon-targeted reporter gene we find that drl is expressed by a small subset of embryonic interneurons whose growth cones choose common pathways during development [3].
  • Learning/memory remained normal when the lio+ transgene was expressed in wild-type (lio+) flies [4].
  • Moreover, Src64 is shown here to act in a cell-autonomous fashion and is likely to interact with the previously-identified linotte/derailed receptor tyrosine kinase in MB development [5].
  • We isolated TIFR specific enhancers from the lio locus and showed that only four interhemispheric cells give rise to this complex fibrous structure [6].
 

Biological context of drl

  • These results suggest that linotte is part of a novel signal transduction cascade involved in learning and memory [1].
  • The data presented here suggest that the memory phenotype of linotte and derailed mutants is a consequence of abnormal brain development due to loss of function of the linotte/derailed encoded receptor tyrosine kinase [7].
  • The linotte mutant was derived from a PlacW transposon mutagenesis and was screened for three-hour memory deficits after classical conditioning of an olfactory avoidance response [8].
  • Like other members of the "related to tyrosine kinases" (RYK) subfamily of RTKs, DRL has several highly unusual amino acid substitutions within the catalytic domain, raising the possibility that members of this subfamily are catalytically inactive [9].
 

Anatomical context of drl

  • In particular, the linotte (lio) mutants display strong structural defects in the mushroom bodies and the central complex [10].
  • The linotte/derailed gene encodes a Drosophila RYK subfamily member involved in embryonic and adult central nervous system development [11].
  • Gal4 enhancer-trap lines used as cell markers revealed that in lio mutants central brain axons behave as if they were abnormally attracted by the midbrain area [12].
  • The Drosophila Derailed (DRL) receptor tyrosine kinase (RTK) controls key guidance events in the developing nervous system and mesoderm [9].
 

Associations of drl with chemical compounds

  • To test the role of DRL kinase activity in vivo, we mutated the invariant lysine required for catalytic activity of known kinases and examined the ability of this mutant to function in two assays: a dominant gain-of-function axon switch assay in the nervous system and phenotypic rescue of muscle attachment in drl mutants [9].
 

Analytical, diagnostic and therapeutic context of drl

  • Molecular cloning of linotte in Drosophila: a novel gene that functions in adults during associative learning [4].

References

  1. The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product. Dura, J.M., Taillebourg, E., Préat, T. FEBS Lett. (1995) [Pubmed]
  2. Wnt-mediated axon guidance via the Drosophila Derailed receptor. Yoshikawa, S., McKinnon, R.D., Kokel, M., Thomas, J.B. Nature (2003) [Pubmed]
  3. Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member. Callahan, C.A., Muralidhar, M.G., Lundgren, S.E., Scully, A.L., Thomas, J.B. Nature (1995) [Pubmed]
  4. Molecular cloning of linotte in Drosophila: a novel gene that functions in adults during associative learning. Bolwig, G.M., Del Vecchio, M., Hannon, G., Tully, T. Neuron (1995) [Pubmed]
  5. Gain-of-function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development. Nicolaï, M., Lasbleiz, C., Dura, J.M. J. Neurobiol. (2003) [Pubmed]
  6. no-bridge and linotte act jointly at the interhemispheric junction to build up the adult central brain of Drosophila melanogaster. Hitier, R., Simon, A.F., Savarit, F., Préat, T. Mech. Dev. (2000) [Pubmed]
  7. Mutation of linotte causes behavioral defects independently of pigeon in Drosophila. Moreau-Fauvarque, C., Taillebourg, E., Préat, T., Dura, J.M. Neuroreport (2002) [Pubmed]
  8. Identification of linotte, a new gene affecting learning and memory in Drosophila melanogaster. Dura, J.M., Preat, T., Tully, T. J. Neurogenet. (1993) [Pubmed]
  9. The derailed guidance receptor does not require kinase activity in vivo. Yoshikawa, S., Bonkowsky, J.L., Kokel, M., Shyn, S., Thomas, J.B. J. Neurosci. (2001) [Pubmed]
  10. Central brain postembryonic development in Drosophila: implication of genes expressed at the interhemispheric junction. Boquet, I., Hitier, R., Dumas, M., Chaminade, M., Préat, T. J. Neurobiol. (2000) [Pubmed]
  11. In vivo evidence for a regulatory role of the kinase activity of the linotte/derailed receptor tyrosine kinase, a Drosophila Ryk ortholog. Taillebourg, E., Moreau-Fauvarque, C., Delaval, K., Dura, J.M. Dev. Genes Evol. (2005) [Pubmed]
  12. The Drosophila putative kinase linotte (derailed) prevents central brain axons from converging on a newly described interhemispheric ring. Simon, A.F., Boquet, I., Synguélakis, M., Préat, T. Mech. Dev. (1998) [Pubmed]
 
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