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Gene Review

ph-d  -  polyhomeotic distal

Drosophila melanogaster

Synonyms: CG3895, DROZFP, Dmel\CG3895, EG:BACN25G24.3, PH, ...
 
 
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High impact information on ph-d

 

Biological context of ph-d

  • As the number of functional copies of ph increases in the same genome, a concomitant reduction of the transcription of each copy is observed [5].
  • The negative autoregulation of ph starts at the blastoderm stage and is partly mediated by a transvection effect [5].
  • Analysis of null alleles of ph has revealed a complex, embryonically lethal phenotype that includes cell death of the ventral epidermis and abnormalities in the patterns of expression of homeotic and segmentation genes [6].
  • polyhomeotic: a gene required for the embryonic development of axon pathways in the central nervous system of Drosophila [6].
  • Tissue- and stage-specific control of homeotic and segmentation gene expression in Drosophila embryos by the polyhomeotic gene [7].
 

Anatomical context of ph-d

 

Associations of ph-d with chemical compounds

  • Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain [13].
 

Other interactions of ph-d

 

Analytical, diagnostic and therapeutic context of ph-d

References

  1. Cosuppression in Drosophila: gene silencing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent. Pal-Bhadra, M., Bhadra, U., Birchler, J.A. Cell (1997) [Pubmed]
  2. A complex genetic locus, polyhomeotic, is required for segmental specification and epidermal development in D. melanogaster. Dura, J.M., Randsholt, N.B., Deatrick, J., Erk, I., Santamaria, P., Freeman, J.D., Freeman, S.J., Weddell, D., Brock, H.W. Cell (1987) [Pubmed]
  3. polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila. Fauvarque, M.O., Dura, J.M. Genes Dev. (1993) [Pubmed]
  4. The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome-binding sites with Polycomb. DeCamillis, M., Cheng, N.S., Pierre, D., Brock, H.W. Genes Dev. (1992) [Pubmed]
  5. Regulation of polyhomeotic transcription may involve local changes in chromatin activity in Drosophila. Fauvarque, M.O., Zuber, V., Dura, J.M. Mech. Dev. (1995) [Pubmed]
  6. polyhomeotic: a gene required for the embryonic development of axon pathways in the central nervous system of Drosophila. Smouse, D., Goodman, C., Mahowald, A., Perrimon, N. Genes Dev. (1988) [Pubmed]
  7. Tissue- and stage-specific control of homeotic and segmentation gene expression in Drosophila embryos by the polyhomeotic gene. Dura, J.M., Ingham, P. Development (1988) [Pubmed]
  8. polyhomeotic is required for somatic cell proliferation and differentiation during ovarian follicle formation in Drosophila. Narbonne, K., Besse, F., Brissard-Zahraoui, J., Pret, A.M., Busson, D. Development (2004) [Pubmed]
  9. Polyhomeotic stably associates with molecular chaperones Hsc4 and Droj2 in Drosophila Kc1 cells. Wang, Y.J., Brock, H.W. Dev. Biol. (2003) [Pubmed]
  10. Identification and characterization of polyhomeotic PREs and TREs. Bloyer, S., Cavalli, G., Brock, H.W., Dura, J.M. Dev. Biol. (2003) [Pubmed]
  11. polyhomeotic controls engrailed expression and the hedgehog signaling pathway in imaginal discs. Randsholt, N.B., Maschat, F., Santamaria, P. Mech. Dev. (2000) [Pubmed]
  12. Alternative transcripts of a polyhomeotic gene homolog are expressed in distinct regions of somites during segmentation of zebrafish embryos. Kawamura, A., Yamada, K., Fujimori, K., Higashinakagawa, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  13. Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain. Wang, J., Lee, C.H., Lin, S., Lee, T. Development (2006) [Pubmed]
  14. Localization in situ of polyhomeotic transcripts in Drosophila embryos reveals spatially restricted expression beginning at the blastoderm stage. Deatrick, J. Dev. Genet. (1992) [Pubmed]
  15. polyhomeotic appears to be a target of engrailed regulation in Drosophila. Serrano, N., Brock, H.W., Demeret, C., Dura, J.M., Randsholt, N.B., Kornberg, T.B., Maschat, F. Development (1995) [Pubmed]
  16. A Drosophila ESC-E(Z) protein complex is distinct from other polycomb group complexes and contains covalently modified ESC. Ng, J., Hart, C.M., Morgan, K., Simon, J.A. Mol. Cell. Biol. (2000) [Pubmed]
  17. Genetic dissection of a complex neurological mutant, polyhomeotic, in Drosophila. Smouse, D., Perrimon, N. Dev. Biol. (1990) [Pubmed]
 
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