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GIF  -  gastric intrinsic factor (vitamin B...

Canis lupus familiaris

 
 
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Disease relevance of GIF

 

High impact information on GIF

  • When 50% occlusion of the vessel developed, the current was stopped and animals received an intravenous bolus of either saline, bovine glutamyl-glycyl-arginyl-Factor IXa (IXai), a competitive inhibitor of Factor IXa assembly into the intrinsic Factor X activation complex, bovine Factor IX, or heparin [2].
  • Despite increases in NHGU, net hepatic lactate release did not increase in SHAM and fell in INF [3].
  • On the third day of TPN administration, a sterile (SHAM, n = 12) or Escherichia coli-containing (INF, n = 11) fibrin clot was implanted in the peritoneal cavity [4].
  • Infection increased hepatic blood flow (35 +/- 5 vs. 47+/-3 ml x g(-1) x min(-1); SH vs. INF) and basal glucose rate of appearance (2.1+/-0.2 vs. 3.3+/-0.1 mg x kg(-1) x min(-1)) [5].
  • A cellular source of pancreatic intrinsic factor has not been previously described, and the demonstration of intrinsic factor-like immunoreactivity in two cell types in the canine stomach contrasts with its localization in a single cell type in the gastric mucosa of other mammalian species [6].
 

Biological context of GIF

 

Anatomical context of GIF

 

Analytical, diagnostic and therapeutic context of GIF

  • In the present study, an RT-PCR method has been standardised and employed to evaluate the frequency and the semi-quantitative level of expression of the cytokines IL-4, IL-10, IL-12, INF-gamma and TNF-alpha in splenocytes of 30 dogs naturally infected with Leishmania chagasi and of 7 non-infected dogs (NID) [9].
  • Cyano [57Co]cobalamin was introduced into ileal loops in dogs under general anesthesia, either free (control) or bound to gastric or pancreatic intrinsic factor [8].

References

  1. Impact of intraportal N(omega)-nitro-L-arginine infusion on hepatic glucose metabolism in total parenteral nutrition-adapted dogs: interaction with infection. Chen, S.S., Donmoyer, C.M., Ejiofor, J., McCay, J., Archuletta, R., Lacy, D.B., McGuinness, O.P. Metab. Clin. Exp. (2002) [Pubmed]
  2. Active site-blocked factor IXa prevents intravascular thrombus formation in the coronary vasculature without inhibiting extravascular coagulation in a canine thrombosis model. Benedict, C.R., Ryan, J., Wolitzky, B., Ramos, R., Gerlach, M., Tijburg, P., Stern, D. J. Clin. Invest. (1991) [Pubmed]
  3. Infection impairs insulin-dependent hepatic glucose uptake during total parenteral nutrition. Donmoyer, C.M., Chen, S.S., Lacy, D.B., Pearson, D.A., Poole, A., Zhang, Y., McGuinness, O.P. Am. J. Physiol. Endocrinol. Metab. (2003) [Pubmed]
  4. Fructose augments infection-impaired net hepatic glucose uptake during TPN administration. Donmoyer, C.M., Ejiofor, J., Lacy, D.B., Chen, S.S., McGuinness, O.P. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
  5. Hepatic glucose metabolism during intraduodenal glucose infusion: impact of infection. McGuinness, O.P., Ejiofor, J., Lacy, D.B., Schrom, N. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  6. Cellular localization of intrinsic factor in pancreas and stomach of the dog. Vaillant, C., Horadagoda, N.U., Batt, R.M. Cell Tissue Res. (1990) [Pubmed]
  7. Intrinsic factor-mediated intestinal absorption of cobalamin in the dog. Marcoullis, G., Rothenberg, S.P. Am. J. Physiol. (1981) [Pubmed]
  8. Gastric and pancreatic intrinsic factor-mediated absorption of cobalamin in the dog. Batt, R.M., Horadagoda, N.U. Am. J. Physiol. (1989) [Pubmed]
  9. Analysis of the cytokine profile in spleen cells from dogs naturally infected by Leishmania chagasi. Lage, R.S., Oliveira, G.C., Busek, S.U., Guerra, L.L., Giunchetti, R.C., Corr??a-Oliveira, R., Reis, A.B. Vet. Immunol. Immunopathol. (2007) [Pubmed]
 
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