Gene Review:
CXCR4 - chemokine (C-X-C motif) receptor 4
Pan troglodytes
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Disease relevance of CXCR4
- Chimpanzee CXCR4 was found to be identical to human CXCR4, which provides an explanation for the sensitivity of chimpanzees to lymphotropic isolates of HIV-1 [1].
- Chimpanzee CXCR4 and CCR5 act as coreceptors for HIV type 1 [1].
Analytical, diagnostic and therapeutic context of CXCR4
- As chimpanzees are the animal model for infection by HIV-1, we cloned and sequenced chimpanzee CXCR4 and CCR5 from PBMCs [1].
References
- Chimpanzee CXCR4 and CCR5 act as coreceptors for HIV type 1. Prétet, J.L., Zerbib, A.C., Girard, M., Guillet, J.G., Butor, C. AIDS Res. Hum. Retroviruses (1997) [Pubmed]
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