Disease relevance of ix

• Intersexuality is always correlated with the presence of cytoplasmic viral particles in both intersex-female and transmitter-male tissues [1].

High impact information on ix

• Mutations in either Zn(2+)-binding site or tail can lead to an intersex phenotype [2].
• intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation [3].
• A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex [4].
• In the present study, we report the identification and characterization of a novel human gene, (Drosophila) intersex-like (IXL), from a human embryonic heart cDNA library [5].
• Electron microscopic examination of gonads of Drosophila melanogaster with different genotypes, including a metafemale 3X;2A and an intersex XXY;3A have revealed that the formation of synaptonemal complexes is controlled by the genic balance, i.e., the ratio of X chromosomes to autosomes [6].

Biological context of ix

• The effect of transformer, doublesex and intersex mutations on the sexual behavior of Drosophila melanogaster [7].
• Our molecular genetic characterization of her suggests that her is expressed sex non-specifically and independently of other known sex determination genes and that it acts together with the last genes in the sex determination hierarchy, doublesex and intersex, to control female sexual differentiation [8].

Anatomical context of ix

• Schüpbach (1982, Dev. Biol. 89, 117-127) indicate that the tra-2+ gene functions in the male germ line and thus, in contrast to all other sex determination loci examined to date (doublesex, intersex, transformer), its action is not limited to the soma [9].

Other interactions of ix

• To test this, we cloned insect and vertebrate homologs of the Drosophila gene intersex (ix), which functions together with dsx at the bottom of the hierarchy in females [10].

Analytical, diagnostic and therapeutic context of ix

• RT-PCR analysis revealed that ma-vas was exclusively expressed in the gonads of the female, intersex, and male [11].

References