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Gene Review:

Acsl - Acyl-CoA synthetase long-chain

Drosophila melanogaster

Synonyms: 7447, CG8732, Dmel\CG8732, FACS, FCS, ...

Oba, Y. et al., Zheng, Y. et al., Oba, Y. et al.

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High impact information on l(2)44DEa

These results suggest that firefly luciferase might be evolved from a fatty acyl-CoA synthetase by gene duplication in insects [1].
The enzymatic properties of CG6178 including substrate specificity, pH dependency and optimal temperature were close to those of firefly luciferase and rat fatty acyl-CoA synthetase [2].
Recently, it was revealed that firefly luciferase has two catalytic functions, monooxygenase (luciferase) and AMP-mediated CoA ligase (fatty acyl-CoA synthetase) [2].
Protein motif analysis of the BGR-like gene revealed that it contained a conserved adenosine monophosphate (AMP)-binding domain and a fatty acyl-CoA synthetase signature motif which existed in all acyl-CoA synthetases [3].

References

Identification of paralogous genes of firefly luciferase in the Japanese firefly, Luciola cruciata. Oba, Y., Sato, M., Ohta, Y., Inouye, S. Gene (2006) [Pubmed]
Characterization of CG6178 gene product with high sequence similarity to firefly luciferase in Drosophila melanogaster. Oba, Y., Ojika, M., Inouye, S. Gene (2004) [Pubmed]
Identification and characterization of the BGR-like gene with a potential role in human testicular development/spermatogenesis. Zheng, Y., Zhou, Z.M., Min, X., Li, J.M., Sha, J.H. Asian J. Androl. (2005) [Pubmed]

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AgaP_AGAP003623	Anopheles gambiae str. PEST
LACS8	Arabidopsis thaliana
ACSL3	Bos taurus
ACSL3	Canis lupus familiaris
acsl3b	Danio rerio
acsl3a	Danio rerio
ACSL3	Gallus gallus
ACSL3	Homo sapiens
ACSL3	Macaca mulatta
Acsl3	Mus musculus
Os05g0317200	Oryza sativa Japonica Group
ACSL3	Pan troglodytes
Acsl3	Rattus norvegicus
acsl4	Xenopus (Silurana) tropicalis

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