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Gene Review

TPH2  -  tryptophan hydroxylase 2

Pan troglodytes

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High impact information on TPH2

  • Tryptophan hydroxylase 2 (TPH2) is a rate-limiting enzyme of neuronal serotonin biosynthesis [1].


  1. A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats. Hong, K.W., Sugawara, Y., Hasegawa, H., Hayasaka, I., Hashimoto, R., Ito, S., Inoue-Murayama, M. Neurosci. Lett. (2007) [Pubmed]
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