Gene Review:
BRAF - v-raf murine sarcoma viral oncogene...
Canis lupus familiaris
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Disease relevance of BRAF
- The purpose of this study was to determine if BRAF mutations occur in canine oral malignant melanomas [1].
- An activating mutation in codon 599 of BRAF has been identified in approximately 60% of human cutaneous nevi and melanomas, but not melanomas of mucosal origin [1].
High impact information on BRAF
- To screen canine melanoma samples for BRAF mutation in codon 599, cDNA and genomic DNA were isolated from canine malignant melanoma cell lines and primary tumor samples respectively, all from cases seen at the Veterinary Medical Teaching Hospital at the University of California, Davis [1].
- However, all of the melanoma cell lines expressed BRAF and demonstrated high levels of basal ERK phosphorylation suggesting that dysregulation of this pathway is present [1].
Biological context of BRAF
- Exon 15 BRAF mutations are uncommon in canine oral malignant melanomas [1].
References
- Exon 15 BRAF mutations are uncommon in canine oral malignant melanomas. Shelly, S., Chien, M.B., Yip, B., Kent, M.S., Theon, A.P., McCallan, J.L., London, C.A. Mamm. Genome (2005) [Pubmed]
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