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Gene Review

MBP  -  myelin basic protein

Canis lupus familiaris

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Disease relevance of MBP

  • Whether an immune response to MBP plays an immunopathogenic role in the chronic, demyelinating phase of canine distemper encephalitis remains to be determined [1].
  • Dogs with severe demyelination had elevated values of immunoreactive MBP while dogs with only mild inflammation had little or none [1].
  • Rabbit antiserum raised against a recombinant fusion protein of O. volvulus, MBP/OvD 5B (Ov33), was found to react with a 31-33 kDa glycoprotein (DiT33) of adult worms of D. immitis [2].
  • However, the postradiation hypotension was only somewhat affected, with the MBP falling to a level 28% below the preradiation level [3].
  • Synthetic peptide S24 (TTHYGSLPQKG) represents residues 65-74 of myelin basic protein (MBP) and contains the major determinant involved in the development of experimental allergic encephalomyelitis (EAE) in rabbits [4].

Psychiatry related information on MBP

  • Meanwhile, the MBP level in the CSF may be a sensitive biological indicator for brain damage at the early stage of trauma-related stress disorder [5].

High impact information on MBP

  • Mutations in the myelin basic protein gene lead to a lack of protein, resulting in changes in the structure of myelin, which can be rescued by transgenic complementation [6].
  • A rabbit B cell determinant for a conserved portion of myelin basic protein, rabbit encephalitogenic sequence 65-74 [4].
  • Both 38 and 44 kDa MBP kinase activities increased significantly during contractions induced by 10 microM acetylcholine, 0.1 microM neurokinin A and 70 mM potassium [7].
  • Exogenous proteins which could also be phosphorylated by the purified protein kinase were skeletal muscle glycogen synthase greater than gizzard myosin light chain greater than brain myelin basic protein greater than casein [8].
  • The polyadenylated RNA directing the synthesis of the rat myelin basic proteins is present in both free and membrane-bound forebrain polyribosomes [9].

Biological context of MBP

  • An antibody response to MBP/OvD 5B was observed in dogs, as early as 11 weeks post infection with infective larvae of D. immitis, and in dogs with occult infection [2].
  • An MBP/Di-NHR-7 fusion protein is able to bind to DNA response elements that are recognized by the closely related mammalian NR Rev-erb(alpha) [10].
  • Bimakalim reduced mean aortic blood pressure (MBP, 25 mm Hg) during the occlusion and reperfusion periods in the group of dogs that received the drug throughout the experiment and reduced in BP, during reperfusion when administered immediately before the reperfusion period [11].
  • Twenty-four-hour values (mean +/- SD) were obtained for SBP (121 +/- 22 mmHg), DBP (86 +/- 17 mmHg), mean BP (MBP, 98 +/- 18 mmHg) and heart rate (73 +/- 16 bpm) [12].
  • We therefore studied the effect of human MBP on ion transport in dog tracheal epithelium [13].

Anatomical context of MBP

  • These results suggest that the oligodendrocyte in vitro expresses MAG before MBP [14].
  • At three time points post-infection (PI), immunoreactive myelin basic protein (MBP) was measured in cerebrospinal fluid (CSF) [1].
  • The isolated myelin fractions contained very little MBP (less than 0.5% of total protein) or proteolipid protein, indicating that they were a very immature form of myelin or consisted largely of non-myelin contaminants [15].
  • Instillation of MBP directly into the subepithelial tracheal smooth muscle did not alter contraction [16].
  • The MBP level was markedly increased in the CSF (p < 0.01) in the two trauma groups, in the hypothalamus of the low-speed trauma group (p < 0.05), and in both the hypothalamus and the hippocampus of the high-speed trauma group (p < 0.01) [5].

Associations of MBP with chemical compounds

  • The response to intra-arterial acetylcholine (ACh) was augmented substantially in five dogs receiving 200 micrograms MBP by intraepithelial instillation [16].
  • In conclusion, GM1 ganglioside, AST, LDH, NSE and MBP could be utilized as CSF biomarkers showing CNS degeneration in dogs with GM1 gangliosidosis to evaluate the efficacy of novel therapies proposed for this disease [17].
  • Resting values of LVEF, FS, +LVdP/dt, and MBP remained unchanged whatever the drug and the dosing regimen, whereas resting HR was significantly and dose-dependently lowered after dronedarone and to a lesser extent after amiodarone [18].
  • After exposure to MBP, prostaglandin E2 release into the serosal bathing solution increased from 10.0 +/- 4.2 to 17.0 +/- 6.9 (p less than 0.05) [13].
  • The addition of MBP (5 X 10(-6) M) to the mucosal, but not to the serosal, side of the membranes produced an increase in short-circuit current from 2.25 +/- 0.19 (mean +/- SE) to 2.78 +/- 0.23 (p less than 0.0001) and in net chloride secretion from 1.57 +/- 0.22 to 2.31 +/- 0.24 (p less than 0.01) [13].

Analytical, diagnostic and therapeutic context of MBP


  1. Demyelinating canine distemper encephalomyelitis: measurement of myelin basic protein in cerebrospinal fluid. Summers, B.A., Whitaker, J.N., Appel, M.J. J. Neuroimmunol. (1987) [Pubmed]
  2. Expression of an Onchocerca volvulus Ov33 homolog in Dirofilaria immitis: potential in immunodiagnosis of heartworm infection. Santiago Mejia, J., Nkenfou, C., Southworth, M.W., Perler, F.B., Carlow, C.K. Parasite Immunol. (1994) [Pubmed]
  3. Antihistamines block radiation-induced increased intestinal blood flow in canines. Cockerham, L.G., Doyle, T.F., Donlon, M.A., Gossett-Hagerman, C.J. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1985) [Pubmed]
  4. A rabbit B cell determinant for a conserved portion of myelin basic protein, rabbit encephalitogenic sequence 65-74. Lazarus, K.J., Hashim, G.A., Varitek, V.A., Paterson, P.Y., Day, E.D. J. Immunol. (1983) [Pubmed]
  5. Alterations of myelin basic protein and ultrastructure in the limbic system at the early stage of trauma-related stress disorder in dogs. Wang, Q., Wang, Z., Zhu, P., Jiang, J. The Journal of trauma. (2004) [Pubmed]
  6. Myelin mutants: model systems for the study of normal and abnormal myelination. Griffiths, I.R. Bioessays (1996) [Pubmed]
  7. Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle. Gerthoffer, W.T., Yamboliev, I.A., Shearer, M., Pohl, J., Haynes, R., Dang, S., Sato, K., Sellers, J.R. J. Physiol. (Lond.) (1996) [Pubmed]
  8. Purification and characterization of a calcium-calmodulin-dependent phospholamban kinase from canine myocardium. Gupta, R.C., Kranias, E.G. Biochemistry (1989) [Pubmed]
  9. The polyadenylated RNA directing the synthesis of the rat myelin basic proteins is present in both free and membrane-bound forebrain polyribosomes. Hall, C., Mahadevan, L.C., Whatley, S.A., Ling, T.S., Lim, L. Biochem. J. (1982) [Pubmed]
  10. Dirofilaria immitis encodes Di-nhr-7, a putative orthologue of the Drosophila ecdysone-regulated E78 gene. Crossgrove, K., Laudet, V., Maina, C.V. Mol. Biochem. Parasitol. (2002) [Pubmed]
  11. Reduction in myocardial infarct size by the new potassium channel opener bimakalim. Auchampach, J.A., Gross, G.J. J. Cardiovasc. Pharmacol. (1994) [Pubmed]
  12. Circadian rhythms in blood pressure in free-ranging three-toed sloths (Bradypus variegatus). Duarte, D.P., Silva, V.L., Jaguaribe, A.M., Gilmore, D.P., Da Costa, C.P. Braz. J. Med. Biol. Res. (2003) [Pubmed]
  13. Effect of human eosinophil major basic protein on ion transport in dog tracheal epithelium. Jacoby, D.B., Ueki, I.F., Widdicombe, J.H., Loegering, D.A., Gleich, G.J., Nadel, J.A. Am. Rev. Respir. Dis. (1988) [Pubmed]
  14. Myelin-associated glycoprotein is produced before myelin basic protein in cultured oligodendrocytes. Zurbriggen, A., Vandevelde, M., Steck, A., Angst, B. J. Neuroimmunol. (1984) [Pubmed]
  15. Myelin proteins in the CNS of 'shaking pups'. Inuzuka, T., Duncan, I.D., Quarles, R.H. Brain Res. (1986) [Pubmed]
  16. Epithelial augmentation of trachealis contraction caused by major basic protein of eosinophils. Brofman, J.D., White, S.R., Blake, J.S., Munoz, N.M., Gleich, G.J., Leff, A.R. J. Appl. Physiol. (1989) [Pubmed]
  17. Cerebrospinal fluid biomarkers showing neurodegeneration in dogs with GM1 gangliosidosis: Possible use for assessment of a therapeutic regimen. Satoh, H., Yamato, O., Asano, T., Yonemura, M., Yamauchi, T., Hasegawa, D., Orima, H., Arai, T., Yamasaki, M., Maede, Y. Brain Res. (2007) [Pubmed]
  18. Hemodynamic and antiadrenergic effects of dronedarone and amiodarone in animals with a healed myocardial infarction. Djandjighian, L., Planchenault, J., Finance, O., Pastor, G., Gautier, P., Nisato, D. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  19. A study of the techniques of cardiac massage with the abdomen open. Rieder, C.F., Crawford, B.G., Iliopoulos, J.I., Thomas, J.H., Pierce, G.E., Hermreck, A.S. Surgery (1985) [Pubmed]
  20. Restricted infection with canine distemper virus leads to down-regulation of myelin gene transcription in cultured oligodendrocytes. Graber, H.U., Müller, C.F., Vandevelde, M., Zurbriggen, A. Acta Neuropathol. (1995) [Pubmed]
  21. Lymphocyte responsiveness to lectin and myelin antigens in canine distemper infection in relation to the development of demyelinating lesions. Cerruti-Sola, S., Kristensen, F., Vandevelde, M., Bichsel, P., Kihm, U. J. Neuroimmunol. (1983) [Pubmed]
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