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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CXCR4  -  chemokine (C-X-C motif) receptor 4

Canis lupus familiaris

 
 
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Disease relevance of CXCR4

  • CXCR4-PMPLs specifically bound the natural ligand, SDF-1alpha, and the gp120s from CXCR4-using HIV-1 strains [1].
  • 9. RESULTS: The model human erythroleukemia (HEL) cell line, exhibiting megakaryocytic-like properties, expressed CCR5, CCR3, CXCR4, and CPR15/BOB, and all viruses except YU2 (R5) efficiently entered the cells [2].
 

High impact information on CXCR4

  • Peripheral-blood mononuclear cells (PBMCs) mobilized with AMD3100, a CXCR4 antagonist, combined with granulocyte colony-stimulating factor (G-CSF) have reconstituted autologous hematopoiesis in cancer patients following myeloablative conditioning [3].
  • Conformation-dependent anti-CXCR4 antibodies and the CXCR4 antagonist AMD3100 blocked HIV-1 gp120 binding to CXCR4-PMPLs [1].
  • We studied the binding of the HIV-1 gp120 envelope glycoprotein (gp) to CXCR4 but found that the gp120s from CXCR4-using HIV-1 strains bound nonspecifically to several cell lines lacking human CXCR4 expression [1].
  • Both angioblasts and endothelial cells expressed CXCR4, a marker for hemangioblasts [4].

References

  1. Ligand binding characteristics of CXCR4 incorporated into paramagnetic proteoliposomes. Babcock, G.J., Mirzabekov, T., Wojtowicz, W., Sodroski, J. J. Biol. Chem. (2001) [Pubmed]
  2. Expression and utilization of co-receptors in HIV and simian immunodeficiency virus infection of megakaryocytes. Park, I.W., Wang, J.F., Groopman, J.E. AIDS (1999) [Pubmed]
  3. Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral-blood mononuclear cells in a canine transplantation model. Burroughs, L., Mielcarek, M., Little, M.T., Bridger, G., Macfarland, R., Fricker, S., Labrecque, J., Sandmaier, B.M., Storb, R. Blood (2005) [Pubmed]
  4. Canine retinal angioblasts are multipotent. Lutty, G.A., Merges, C., Grebe, R., Prow, T., McLeod, D.S. Exp. Eye Res. (2006) [Pubmed]
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