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Gene Review:

PTAFR - platelet-activating factor receptor

Canis lupus familiaris

Bernat, A. et al., Piper, P.J. et al., Kochanek, P.M. et al.

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Disease relevance of PTAFR

Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia [1].

High impact information on PTAFR

Pretreatment with SR 49059 (1 mg/kg I.V.) and SR 27417 (a platelet-activating factor receptor antagonist) (1 mg/kg I.V.) had no effect on the DDAVP-induced (1 microg/kg I.V.) increases in FVIII, vWF and t-PA plasma levels [2].
Antagonism of vasoconstriction induced by platelet-activating factor in guinea-pig perfused hearts by selective platelet-activating factor receptor antagonists [3].

References

Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia. Kochanek, P.M., Dutka, A.J., Kumaroo, K.K., Hallenbeck, J.M. Life Sci. (1987) [Pubmed]
V2 receptor antagonism of DDAVP-induced release of hemostasis factors in conscious dogs. Bernat, A., Hoffmann, P., Dumas, A., Serradeil-le Gal, C., Raufaste, D., Herbert, J.M. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
Antagonism of vasoconstriction induced by platelet-activating factor in guinea-pig perfused hearts by selective platelet-activating factor receptor antagonists. Piper, P.J., Stewart, A.G. Br. J. Pharmacol. (1987) [Pubmed]

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