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Gene Review:

ECE1 - endothelin converting enzyme 1

Canis lupus familiaris

Wada, A. et al., Wang, X. et al., Wood, J.G. et al., Motte, S. et al.

Wada, Tsutamoto, Ohnishi, Sawaki, Fukai, Maeda, Kinoshita,

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Disease relevance of ECE1

Effects of a specific endothelin-converting enzyme inhibitor on cardiac, renal, and neurohumoral functions in congestive heart failure: comparison of effects with those of endothelin A receptor antagonism [1].

High impact information on ECE1

Two incremental doses of a specific ECE inhibitor, FR901533, or a selective ETA receptor antagonist, FR139317 (1 and 3 mg/kg, n=8, respectively), were injected into dogs with CHF [1].
Endothelin-1 promotes vascular structural remodeling during the progression of heart failure prevention of vascular remodeling using a specific endothelin-converting enzyme inhibitor [2].

Associations of ECE1 with chemical compounds

In other experiments, using 15-min peptide infusions, we found that pretreatment with phosphoramidon, an inhibitor of endothelin-converting enzyme, markedly reduced response to big endothelin-1 but not to endothelin-1 [3].

Analytical, diagnostic and therapeutic context of ECE1

Real-time quantitative PCR was used for determinations of tissue prepro-ET-1 (ppET-1), ET-1-converting enzyme (ECE-1), and ETA and ETB receptor mRNA [4].

References

Effects of a specific endothelin-converting enzyme inhibitor on cardiac, renal, and neurohumoral functions in congestive heart failure: comparison of effects with those of endothelin A receptor antagonism. Wada, A., Tsutamoto, T., Ohnishi, M., Sawaki, M., Fukai, D., Maeda, Y., Kinoshita, M. Circulation (1999) [Pubmed]
Endothelin-1 promotes vascular structural remodeling during the progression of heart failure prevention of vascular remodeling using a specific endothelin-converting enzyme inhibitor. Wang, X., Ohnishi, M., Wada, A., Tsutamoto, T., Sawaki, M., Fujii, M., Matsumoto, T., Yamamoto, T., Kurokawa, K., Yamada, H., Kinoshita, M. Life Sci. (2001) [Pubmed]
Phosphoramidon attenuates big endothelin-1-induced vasoconstriction in canine stomach. Wood, J.G., Yan, Z.Y., Davis, J.M., Cheung, L.Y. Am. J. Physiol. (1994) [Pubmed]
Early activation of cardiac and renal endothelin systems in experimental heart failure. Motte, S., van Beneden, R., Mottet, J., Rondelet, B., Mathieu, M., Havaux, X., Lause, P., Clercx, C., Ketelslegers, J.M., Naeije, R., McEntee, K. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]

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