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Gene Review

TNS1  -  tensin 1

Canis lupus familiaris

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Disease relevance of TNS1


High impact information on TNS1

  • OBJECTIVE: To determine whether changes in expression level of the phosphatase and tensin homolog deleted on the chromosome 10 (PTEN) gene are associated with malignant transformation in mammary gland tumors in dogs [2].
  • To achieve this goal, we tested a semi-automatic assay combining wheat germ lectin (WGL) precipitation and chemical inhibition of isoenzymes of the TNS gene with levamisole to quantify bone ALP (BALP) and corticosteroid-induced ALP (CALP), respectively [3].

Enzymatic interactions of TNS1

  • We examined the presence of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) abnormalities that could contribute to the origin or progression of naturally occurring canine endothelial tumors (hemangiosarcoma) [1].


  1. Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma. Dickerson, E.B., Thomas, R., Fosmire, S.P., Lamerato-Kozicki, A.R., Bianco, S.R., Wojcieszyn, J.W., Breen, M., Helfand, S.C., Modiano, J.F. Vet. Pathol. (2005) [Pubmed]
  2. Expression of the PTEN tumor suppressor gene in malignant mammary gland tumors of dogs. Kanae, Y., Endoh, D., Yokota, H., Taniyama, H., Hayashi, M. Am. J. Vet. Res. (2006) [Pubmed]
  3. Separation and quantification of corticosteroid-induced, bone and liver alkaline phosphatase isoenzymes in canine serum. Syakalima, M., Takiguchi, M., Yasuda, J., Hashimoto, A. Zentralblatt für Veterinärmedizin. Reihe A. (1997) [Pubmed]
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