Gene Review:
htt - huntingtin
Xenopus (Silurana) tropicalis
Synonyms:
hd, huntington, it15
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High impact information on hd
- RESULTS: The C. intestinalis htt transcript exhibits some peculiar features, such as spliced leader trans-splicing in the 98 nt-long 5' untranslated region (UTR), an alternative splicing in the coding region, eight alternative polyadenylation sites, and no similarities of both 5' and 3'UTRs compared to homologs of the cogeneric C. savignyi [1].
- CONCLUSION: During chordate diversification, events of gain/loss, sliding, phase changes, and expansion of introns occurred in both vertebrate and ascidian lineages predominantly in the 5'-half of the htt gene, where there is also evidence of lineage-specific evolutionary dynamics in vertebrates [1].
- The exon-intron organization of the htt gene is almost identical among vertebrates, and significantly conserved between Ciona and vertebrates, allowing us to hypothesize an ancestral chordate gene consisting of at least 40 coding exons [1].
References
- Huntingtin gene evolution in Chordata and its peculiar features in the ascidian Ciona genus. Gissi, C., Pesole, G., Cattaneo, E., Tartari, M. BMC Genomics (2006) [Pubmed]
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