Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

IL5 - interleukin 5 (colony-stimulating factor,...

Felis catus

Hawken, R.J. et al., Padrid, P.A. et al., Böttcher, M.F. et al., Verhoef, A. et al., Lönnkvist, K. et al., et al.

Verhoef, Alexander, Kay, Larché,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of IL5

BACKGROUND: Eotaxin and interleukin-5 together provide the signal essential for eosinophil transmigration to airway tissue in allergic reactions [1].

High impact information on IL5

A 272 base pair genomic IL5 polymerase chain reaction (PCR) product spanning exon 3, intron 3, and exon 4 was generated using stripe-faced dunnart (Sminthopsis macroura) DNA [2].
Sequencing revealed that the tammar wallaby IL5 gene consists of four exons separated by three introns [2].
Fluorescence in situ hybridization using DNA from the IL5 clone on tammar wallaby chromosomes indicated that the IL5 gene is located on Chromosome 1 [2].
A polymorphic complex compound microsatellite was identified within intron 2 of the tammar wallaby IL5 gene [2].
The genomic nucleotide sequence and chromosomal position of the interleukin 5 (IL5) gene has been described for the model marsupial Macropus eugenii (tammar wallaby) [2].

Biological context of IL5

OBJECTIVE: To clone and characterize the cDNA encoding feline interleukin-5 (IL-5) cDNA and the 170 basepairs (bp) of the 5' flanking region of the feline IL-5 gene [3].
Eosinophil chemotaxis may be a response to the production of interleukin-5 by neoplastic lymphocytes [4].

Anatomical context of IL5

The striking homology between the human and feline IL-5 genes suggests that cats can be used as animal models for human diseases characterized by eosinophil infiltration of tissues [3].

Associations of IL5 with chemical compounds

We hypothesize that allergen-induced Th2, particularly IL-5, responses can be observed in peripheral blood in both atopic and non-atopic asthmatic children but not in healthy control children [5].

Other interactions of IL5

This was associated with modified cytokine profiles generally characterised by an increase in interleukin-10 and a decrease in interleukin-5 production [6].

Analytical, diagnostic and therapeutic context of IL5

This PCR product was used to isolate a genomic lambda clone containing the complete IL5 gene from a tammar wallaby EMBL3 lambda library [2].

References

Increased eosinophil transmigration after nasal allergen challenge in children with allergic asthma and rhinitis. Lönnkvist, K., Moshfegh, A., Pedroletti, C., Hedlin, G., Halldén, G., Lundahl, J. Allergy (2002) [Pubmed]
Isolation and characterization of marsupial IL5 genes. Hawken, R.J., Maccarone, P., Toder, R., Marshall Graves, J.A., Maddox, J.F. Immunogenetics (1999) [Pubmed]
Sequence and structural analysis of feline interleukin-5 cDNA. Padrid, P.A., Qin, Y., Wells, T.N., Solway, J., Camoretti-Mercado, B. Am. J. Vet. Res. (1998) [Pubmed]
Hypereosinophilic paraneoplastic syndrome in a cat with intestinal T cell lymphosarcoma. Barrs, V.R., Beatty, J.A., McCandlish, I.A., Kipar, A. The Journal of small animal practice. (2002) [Pubmed]
Allergen-induced cytokine secretion in atopic and non-atopic asthmatic children. Böttcher, M.F., Bjurström, J., Mai, X.M., Nilsson, L., Jenmalm, M.C. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. (2003) [Pubmed]
T cell epitope immunotherapy induces a CD4+ T cell population with regulatory activity. Verhoef, A., Alexander, C., Kay, A.B., Larché, M. PLoS Med. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.