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Gene Review:

IL16 - interleukin 16

Felis catus

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Disease relevance of IL16

This study extends the data on IL-12 and provides new results on CpG motifs and IL-16 used as adjuvants in the FIV cat model [1].
In addition, the two groups of cats immunized either with gp140 and IL-16 or with gp140 and the CpG had greatly reduced viremia [1].

High impact information on IL16

Four groups of cats, each containing four animals, were immunized at 0, 3, and 6 weeks with minimalistic immunogenic defined gene expression vector (MIDGE) vaccines containing the gene(s) for feline immunodeficiency virus (FIV) gp140, FIV gp140 and feline interleukin-12 (IL-12), FIV gp140 and feline IL-16, or FIV gp140 and a CpG motif [1].
GAPDH mRNAs were readily detectable in cDNAs prepared from unstimulated feline peripheral blood mononuclear cells (PBMCs) and from frozen cell pellets, while cytokines (Interleukin (IL)-4, IL-10, IL-12 p35, IL-12 p40, IFNgamma, IL-16) were expressed at variable amounts [2].

Biological context of IL16

Immunization of cats against feline immunodeficiency virus (FIV) infection by using minimalistic immunogenic defined gene expression vector vaccines expressing FIV gp140 alone or with feline interleukin-12 (IL-12), IL-16, or a CpG motif [1].

Analytical, diagnostic and therapeutic context of IL16

Molecular cloning and expression of feline interleukin-16 [3].

References

Immunization of cats against feline immunodeficiency virus (FIV) infection by using minimalistic immunogenic defined gene expression vector vaccines expressing FIV gp140 alone or with feline interleukin-12 (IL-12), IL-16, or a CpG motif. Leutenegger, C.M., Boretti, F.S., Mislin, C.N., Flynn, J.N., Schroff, M., Habel, A., Junghans, C., Koenig-Merediz, S.A., Sigrist, B., Aubert, A., Pedersen, N.C., Wittig, B., Lutz, H. J. Virol. (2000) [Pubmed]
Quantitative real-time PCR for the measurement of feline cytokine mRNA. Leutenegger, C.M., Mislin, C.N., Sigrist, B., Ehrengruber, M.U., Hofmann-Lehmann, R., Lutz, H. Vet. Immunol. Immunopathol. (1999) [Pubmed]
Molecular cloning and expression of feline interleukin-16. Leutenegger, C.M., Huder, J.B., Hofmann-Lehmann, R., Lutz, H. DNA Seq. (1998) [Pubmed]

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