Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

ITGB2 - integrin, beta 2 (complement component 3...

Ovis aries

Kawata, H. et al., Cooper, J.A. et al., Stevenson, L.M. et al., Kubo, H. et al., Sartorelli, P. et al., et al.

Stevenson, Colditz, Lejambre, Sartorelli, Panelli, Comazzi, Paltrinieri,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CD18

Antibody to CD18 may be useful in myocardial and endothelial protection during surgically induced ischemia [1].

High impact information on CD18

We assessed the effect of preischemic administration of monoclonal antibody to the leukocyte adhesion molecule CD18 on recovery of isolated blood-perfused neonatal lamb hearts arrested for 2 hours with 15 degrees C K+ cardioplegic solution by comparing nine antibody-treated and nine control hearts [1].
These results suggest that leukocyte adherence to endothelium mediated by CD18 plays an important role in reperfusion after hypothermic ischemia [1].
Fibrin serves as a substrate for neutrophil adherence, and this adherence is mediated by expression of the CD18 glycoprotein complex on neutrophils [2].
The effect of infection of sheep with the gastrointestinal nematode parasite Trichostrongylus colubriformis on expression of adhesion molecules CD11a, CD11b, CD11c, CD18, CD44, CD49d and CD62L by peripheral blood eosinophils was examined by flow cytometry [3].
The cDNA of bighorn sheep CD18 has an open reading frame (ORF) of 2310bp [4].

Biological context of CD18

We investigated the mechanisms of increase in the pulmonary vascular permeability, focusing on the changes in the peripheral white blood cell (WBC) counts and the surface expression of CD18 on polymorphonuclear cells (PMNs) [5].
Isolation stress in sheep: effects on neutrophil gene expression of CD18, IL8 and C5a receptors [6].

Associations of CD18 with chemical compounds

Neutrophil adherence to fibrin increased to 81.7 +/- 6.2% with activation by phorbol myristate acetate (10(-8) M) and was inhibited by a monoclonal antibody directed against the beta-chain of the CD18 leukocyte adhesion glycoprotein [2].

Analytical, diagnostic and therapeutic context of CD18

Effect of antibody to leukocyte adhesion molecule CD18 on recovery of neonatal lamb hearts after 2 hours of cold ischemia [1].

References

Effect of antibody to leukocyte adhesion molecule CD18 on recovery of neonatal lamb hearts after 2 hours of cold ischemia. Kawata, H., Aoki, M., Hickey, P.R., Mayer, J.E. Circulation (1992) [Pubmed]
Fibrin is a determinant of neutrophil sequestration in the lung. Cooper, J.A., Lo, S.K., Malik, A.B. Circ. Res. (1988) [Pubmed]
Expression of cell surface adhesion molecules by peripheral blood eosinophils during Trichostrongylus colubriformis infection in sheep. Stevenson, L.M., Colditz, I.G., Lejambre, L.F. Immunol. Cell Biol. (2001) [Pubmed]
Cloning and comparison of bighorn sheep CD18 with that of domestic sheep, goats, cattle, humans and mice. Liu, W., Brayton, K.A., Lagerquist, J., Foreyt, W.J., Srikumaran, S. Vet. Immunol. Immunopathol. (2006) [Pubmed]
Adhesion molecule CD18 on polymorphonuclear cells correlates to the lung injury caused by continuous infusion of endotoxin in sheep. Kubo, H., Tanita, T., Koike, K., Ono, S., Fujimura, S. Tohoku J. Exp. Med. (1995) [Pubmed]
Isolation stress in sheep: effects on neutrophil gene expression of CD18, IL8 and C5a receptors. Sartorelli, P., Panelli, S., Comazzi, S., Paltrinieri, S. Vet. Res. Commun. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.