Gene Review:
perp - PERP, TP53 apoptosis effector
Danio rerio
Synonyms:
SO:0000704, fk24g11, wu:fk24g11
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High impact information on perp
- However, during normal zebrafish development, perp displays a p53-independent and spatially restricted expression in specific cell types and tissues [1].
- Upon overexpression in early zebrafish embryos, perp induces apoptosis [1].
- Antisense-mediated loss of Perp function leads to increased apoptosis in perp-expressing cells of the developing skin and notochord [1].
Biological context of perp
- These different effects are supposed to be mediated by the transcriptional activation of different target genes. perp, encoding a transmembrane protein of the Pmp22 family, is a transcriptional p53 target exclusively upregulated in apoptotic cells [1].
References
- Perp is required for tissue-specific cell survival during zebrafish development. Nowak, M., Köster, C., Hammerschmidt, M. Cell Death Differ. (2005) [Pubmed]
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