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Gene Review:

LAMP-1 - lysosome-associated membrane glycoprotein 1

Sus scrofa

Höning, S. et al., Groos, S. et al.

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High impact information on LAMP-1

The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles [1].
Furthermore, lamp-1 is present in AP-1-positive vesicles and tubules in the trans-region on the Golgi complex [1].
Antibodies directed against the epithelial plasma membrane protein E-cadherin, the lysosomal membrane protein LAMP-1, and the lysosomal matrix protease cathepsin-D were used [2].

Associations of LAMP-1 with chemical compounds

AP-1 binding as well as localization to AP-1 CCVs require the presence of the functional tyrosine-based lysosomal targeting signal of lamp-1 [1].

References

The tyrosine-based lysosomal targeting signal in lamp-1 mediates sorting into Golgi-derived clathrin-coated vesicles. Höning, S., Griffith, J., Geuze, H.J., Hunziker, W. EMBO J. (1996) [Pubmed]
Excessive apoptosis of guinea pig colonocytes may lead to an imbalance between phagocytosis and degradation in vivo. Groos, S., Busche, R., von Engelhardt, W., Reale, E., Luciano, L. Cell Tissue Res. (2004) [Pubmed]

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