Gene Review:
FOXL2 - forkhead box L2
Gallus gallus
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High impact information on FOXL2
- This finding suggests that FOXL2 lies upstream of aromatase in avian sex determination, but that it responds to depleted estrogen synthesis [1].
- The reduction in FOXL2 expression may be accounted for by interruption of a positive feedback loop by means of estrogen, or the influence of testis promoting factors such as SOX9 and DMRT1 in the masculinized gonads [1].
References
- Aromatase inhibition reduces expression of FOXL2 in the embryonic chicken ovary. Hudson, Q.J., Smith, C.A., Sinclair, A.H. Dev. Dyn. (2005) [Pubmed]
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