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CYP1A2  -  cytochrome P450, family 1, subfamily A,...

Bos taurus

 
 
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High impact information on CYP1A2

  • One possible mechanism is a normalizing down-regulation of CYP1A2 expression by bLF, with consequent reduction of carcinogen activation and adduct formation [1].
  • Down-regulation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats [1].
  • By contrast, the olfactory monooxygenases associated with CYP2E1 were poorly or not detected, whereas CYP2G1 and a protein immunorelated to CYP1A2 were expressed in the olfactory epithelium [2].
 

Analytical, diagnostic and therapeutic context of CYP1A2

  • The CYP1A2, CYP2D1, and CYP2B1/2 activities were not affected by BSA, regardless of perfusion time [3].

References

  1. Down-regulation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced CYP1A2 expression is associated with bovine lactoferrin inhibition of MeIQx-induced liver and colon carcinogenesis in rats. Fujita, K., Ohnishi, T., Sekine, K., Iigo, M., Tsuda, H. Jpn. J. Cancer Res. (2002) [Pubmed]
  2. Xenobiotic-metabolizing enzymes in pig nasal and hepatic tissues. Marini, S., Longo, V., Mazzaccaro, A., Gervasi, P.G. Xenobiotica (1998) [Pubmed]
  3. Microsomal cytochrome P450 levels and activities of isolated rat livers perfused with albumin. Vuppugalla, R., Shah, R.B., Chimalakonda, A.P., Fisher, C.W., Mehvar, R. Pharm. Res. (2003) [Pubmed]
 
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