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Gene Review

PABY  -  pseudoautosomal boundary region, Y-linked

Homo sapiens

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High impact information on PABY

  • In the three patients with a dicentric Yq chromosome two different breakpoints were observed; in two it was between PABY and the subtelomeric repeat sequence and in one it was between DYZ5 and AMGY in proximal Yp [1].
  • Fate of SRY, PABY, DYS1, DYZ3 and DYZ1 loci in Indian patients harbouring sex chromosomal anomalies [2].
  • Deletion analyses were performed by polymerase chain reaction (PCR) amplification of Y chromosome-specific DNA sequences (PABY, SRY, DYS250, DYS254, and DYZ1) [3].

Physical interactions of PABY

  • The proximity of SRY to the pseudoautosomal region (PAR) is highly conserved and thus most effectively stabilizes the pseudoautosomal boundary on the Y (PABY) in simians [4].


  1. A molecular and FISH analysis of structurally abnormal Y chromosomes in patients with Turner syndrome. Robinson, D.O., Dalton, P., Jacobs, P.A., Mosse, K., Power, M.M., Skuse, D.H., Crolla, J.A. J. Med. Genet. (1999) [Pubmed]
  2. Fate of SRY, PABY, DYS1, DYZ3 and DYZ1 loci in Indian patients harbouring sex chromosomal anomalies. Bashamboo, A., Rahman, M.M., Prasad, A., Chandy, S.P., Ahmad, J., Ali, S. Mol. Hum. Reprod. (2005) [Pubmed]
  3. SRY mutation and tumor formation on the gonads of XP pure gonadal dysgenesis patients. Uehara, S., Funato, T., Yaegashi, N., Suziki, H., Sato, J., Sasaki, T., Yajima, A. Cancer Genet. Cytogenet. (1999) [Pubmed]
  4. Simian Y chromosomes: species-specific rearrangements of DAZ, RBM, and TSPY versus contiguity of PAR and SRY. Gläser, B., Grützner, F., Willmann, U., Stanyon, R., Arnold, N., Taylor, K., Rietschel, W., Zeitler, S., Toder, R., Schempp, W. Mamm. Genome (1998) [Pubmed]
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