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Gene Review

Hpcal1  -  hippocalcin-like 1

Rattus norvegicus

Synonyms: Hippocalcin-like protein 1, NVL-3, NVP-3, Neural visinin-like protein 3, Nvp3, ...
 
 
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High impact information on Hpcal1

  • Similarily, the calcium-dependent localization of endogenously expressed VILIP-3 and -1 in dendrites differed [1].
  • Therefore, we studied the calcium-dependent localization of green fluorescent protein (GFP)-tagged VILIP-3 in living cell lines and hippocampal neurons and compared it with that of GFP-VILIP-1 [1].
  • These results suggest that NVP-2 and NVP-3 are additional members of the NVP gene family [2].
  • However, the neuronal visinin-like protein-3 gene is also expressed in many ventral nuclei throughout the fore- and midbrain, in the medial habenulae, and in the superior and inferior colliculi.The neuronal calcium sensor proteins are a relatively unexplored family of Ca(2+)-binding proteins [3].
  • Based on this information, antibodies against two recently described calcium-binding proteins, NCS-1 and NVP-3, were biotinylated or digoxigenylated [4].
 

Anatomical context of Hpcal1

  • During development of the cerebellum, NVP3-positive Purkinje cells first appeared on post-natal day 14 (P14) [5].
 

Physical interactions of Hpcal1

  • Expression of neural visinin-like calcium-binding protein 3 (NVP3) was assessed by immunoblot and immunohistochemical analyses in rat brain [5].
 

Analytical, diagnostic and therapeutic context of Hpcal1

  • On SDS-PAGE, native NVP3 migrated at 23kDa, identical to the recombinant myristoyl-form, but somewhat faster than the non-myristoyl-form [5].

References

 
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