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Gene Review

NOSIP  -  nitric oxide synthase interacting protein

Homo sapiens

Synonyms: CGI-25, Nitric oxide synthase-interacting protein, eNOS-interacting protein
 
 
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Disease relevance of NOSIP

 

High impact information on NOSIP

  • Overexpression of NOS-interacting protein (NOSIP) induces translocation of eNOS from the plasma membrane to intracellular compartments, thereby impairing NO production [2].
  • Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton [2].
  • Coimmunoprecipitation studies demonstrated the specific interaction of eNOS and NOSIP in vitro and in vivo, and complex formation was inhibited by a synthetic peptide of the caveolin-1 scaffolding domain [3].
  • We conclude that NOSIP is a novel type of modulator that promotes translocation of eNOS from the plasma membrane to intracellular sites, thereby uncoupling eNOS from plasma membrane caveolae and inhibiting NO synthesis [3].
  • Furthermore, overexpression of NOSIP in cultured primary neurons reduces the availability of nNOS in terminal dendrites [1].
 

Biological context of NOSIP

 

Anatomical context of NOSIP

 

Analytical, diagnostic and therapeutic context of NOSIP

References

  1. Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity. Dreyer, J., Schleicher, M., Tappe, A., Schilling, K., Kuner, T., Kusumawidijaja, G., Müller-Esterl, W., Oess, S., Kuner, R. J. Neurosci. (2004) [Pubmed]
  2. Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton. Schleicher, M., Brundin, F., Gross, S., Müller-Esterl, W., Oess, S. Mol. Cell. Biol. (2005) [Pubmed]
  3. NOSIP, a novel modulator of endothelial nitric oxide synthase activity. Dedio, J., König, P., Wohlfart, P., Schroeder, C., Kummer, W., Müller-Esterl, W. FASEB J. (2001) [Pubmed]
 
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