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Gene Review

ZNF639  -  zinc finger protein 639

Homo sapiens

Synonyms: ANC-2H01, ANC_2H01, ZASC1, Zinc finger protein 639, Zinc finger protein ANC_2H01, ...
 
 
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Disease relevance of ZNF639

 

High impact information on ZNF639

  • ZASC1 was frequently coamplified and subsequently overexpressed with PIK3CA in our panel of ESC cell lines and primary tumors [1].
  • Here, we report the discovery of a novel member of this class, ZASC1, from a recently reported critical region of 3q26 amplification frequently observed in various squamous cell carcinomas, including esophageal squamous cell carcinomas (ESCs) [1].
  • In addition, exogenous expression of ZASC1 promoted the growth of ESC cells, whereas down-regulation of ZASC1 expression by means of an antisense oligonucleotide suppressed the growth of ESC cells [1].
  • The deduced 485-amino acid protein product of ZASC1 contained a putative nuclear localization signal; the exogenously transfected ZASC1 was translocated into cell nuclei [1].
  • By quantitative PCR (Q-PCR), the gene copy numbers of TERC, PI3KCA, ZASC1, and TP63 from microdissected OSCCs have been determined [2].

References

 
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