The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

CDK16  -  cyclin-dependent kinase 16

Homo sapiens

Synonyms: Cell division protein kinase 16, Cyclin-dependent kinase 16, FLJ16665, PCTAIRE, PCTAIRE-motif protein kinase 1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of PCTK1

  • PCTK1 maps distal to the t(X;18) synovial sarcoma breakpoint in Xp11.23 [1].
  • Finally, we found that various forms of PCTAIRE-1 transfected into neuroblastoma cell lines could either promote or inhibit neurite outgrowth, suggesting a potential role for the PCTAIRE-1 gene product in the control of neurite outgrowth [2].
  • UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2 [3].
 

High impact information on PCTK1

 

Biological context of PCTK1

  • The gene (PCTK1) has been mapped to chromosome Xp [1].
  • To analyze the genomic structure and chromosomal location of the PCTAIRE-1 and -3 genes, we isolated human cosmid clones for each gene by screening a human genomic library with murine PCTAIRE cDNA probes [7].
  • PCTAIRE-1 was ubiquitously expressed as a predominant 3.0-kb transcript and a minor 2.2-kb mRNA resulting from differential polyadenylation [8].
  • Two, RPS4 and PCTAIRE1, are already known to escape inactivation; the other 2, of unknown function, include a short cDNA with a full open reading frame and a transcript with no detectable open reading frame [9].
  • Taken together, our findings provide the first demonstration that Pctaire1 phosphorylation of NSF regulates the ability of NSF to oligomerize, implicating an unexpected role of this kinase in modulating exocytosis [5].
 

Anatomical context of PCTK1

  • Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells [2].
  • We show that Pctaire1 encoded two major proteins of M(r) approximately 62,000 and approximately 68,000, found predominantly in testis and brain [10].
  • Within these two tissues, Pctaire1 was most abundant in the cytoplasm of terminally differentiated cells, notably, the pyramidal neurons in brain and elongated spermatids in testis [10].
  • Expression of alternatively spliced PCTAIRE-1 mRNA in PC12 cells and neonatal rat brain [11].
  • We examined the pattern of PCTAIRE-1 protein expression in a number of normal and transformed cell lines of various origins and found that the kinase is ubiquitous [12].
 

Associations of PCTK1 with chemical compounds

  • We have isolated two murine cDNAs designated PCTAIRE-1 and -3 which encode putative serine/threonine-specific protein kinases [8].
 

Regulatory relationships of PCTK1

  • A 420-kb YAC clone positive for PCTK1 also contains the gene coding for ubiquitin-activating enzyme UBE1, previously mapped in Xp11.3, indicating close physical linkage of these genes [1].
  • We found that endogenous PCTAIRE-1 and ectopically expressed PCTAIRE-1 display kinase activity when myelin basic protein is used as an acceptor substrate [12].
 

Other interactions of PCTK1

 

Analytical, diagnostic and therapeutic context of PCTK1

References

  1. Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3. Knight, J.C., Renwick, P.J., Downing, J.R., Okuda, T. Cytogenet. Cell Genet. (1995) [Pubmed]
  2. Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. Graeser, R., Gannon, J., Poon, R.Y., Dubois, T., Aitken, A., Hunt, T. J. Cell. Sci. (2002) [Pubmed]
  3. UHX1 and PCTK1: precise characterisation and localisation within a gene-rich region in Xp11.23 and evaluation as candidate genes for retinal diseases mapped to Xp21.1-p11.2. Brandau, O., Nyakatura, G., Jedele, K.B., Platzer, M., Achatz, H., Ross, M., Murken, J., Rosenthal, A., Meindl, A. Eur. J. Hum. Genet. (1998) [Pubmed]
  4. X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse. Carrel, L., Clemson, C.M., Dunn, J.M., Miller, A.P., Hunt, P.A., Lawrence, J.B., Willard, H.F. Hum. Mol. Genet. (1996) [Pubmed]
  5. Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis. Liu, Y., Cheng, K., Gong, K., Fu, A.K., Ip, N.Y. J. Biol. Chem. (2006) [Pubmed]
  6. Pctaire1 interacts with p35 and is a novel substrate for Cdk5/p35. Cheng, K., Li, Z., Fu, W.Y., Wang, J.H., Fu, A.K., Ip, N.Y. J. Biol. Chem. (2002) [Pubmed]
  7. Cloning of genomic loci and chromosomal localization of the human PCTAIRE-1 and -3 protein kinase genes. Okuda, T., Valentine, V.A., Shapiro, D.N., Downing, J.R. Genomics (1994) [Pubmed]
  8. PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. Okuda, T., Cleveland, J.L., Downing, J.R. Oncogene (1992) [Pubmed]
  9. Escape from X inactivation of two new genes associated with DXS6974E and DXS7020E. Esposito, T., Gianfrancesco, F., Ciccodicola, A., D'Esposito, M., Nagaraja, R., Mazzarella, R., D'Urso, M., Forabosco, A. Genomics (1997) [Pubmed]
  10. The cellular distribution and kinase activity of the Cdk family member Pctaire1 in the adult mouse brain and testis suggest functions in differentiation. Besset, V., Rhee, K., Wolgemuth, D.J. Cell Growth Differ. (1999) [Pubmed]
  11. Expression of alternatively spliced PCTAIRE-1 mRNA in PC12 cells and neonatal rat brain. Gao, C.Y., Chauthaiwale, V.M., Rampalli, A.M., Zelenka, P.S. Gene (1996) [Pubmed]
  12. PCTAIRE-1: characterization, subcellular distribution, and cell cycle-dependent kinase activity. Charrasse, S., Carena, I., Hagmann, J., Woods-Cook, K., Ferrari, S. Cell Growth Differ. (1999) [Pubmed]
  13. Analysis of the interaction between hPFTAIRE1 and PLZF in a yeast two-hybrid system. Gao, Y.K., Jiang, M., Yang, T., Chen, J.Y. Acta Biochim. Biophys. Sin. (Shanghai) (2006) [Pubmed]
  14. Characterization of brain PCTAIRE-1 kinase immunoreactivity and its interactions with p11 and 14-3-3 proteins. Le Bouffant, F., Capdevielle, J., Guillemot, J.C., Sladeczek, F. Eur. J. Biochem. (1998) [Pubmed]
 
WikiGenes - Universities