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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KRT19  -  keratin 19

Bos taurus

 
 
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Disease relevance of LOC514812

  • A new human lung large cell carcinoma cell line producing cytokeratin 19 fragment(CYFRA) and sialyl Lewis X-i antigen(SLX), designated TKB-13, was established from a patent in our laboratory [1].
  • Lung cancer cell line producing cytokeratin 19 fragment and sialyl Lewis X-i antigen [1].
 

High impact information on LOC514812

  • Despite their stratified appearance, both normal urothelium and cultured urothelial cells synthesize mainly K8, K18 and K19, keratins that are typically seen in simple epithelia [2].
  • Notably, the effects of HI were remarkably well-reproduced by polylysine (K19) [3].
  • By indirect immunofluorescence microscopy it was determined that the cytokeratins were distributed cytoplasmically at subconfluent cell densities but that cytokeratin 19 sometimes localized at regions of cell-cell contact after cells reached confluence [4].
  • Immunohistochemically, the neoplastic epithelium was positive for pan-cytokeratin (AE1/AE2) and cytokeratin 19 but was negative for cytokeratin 18 [5].

References

  1. Lung cancer cell line producing cytokeratin 19 fragment and sialyl Lewis X-i antigen. Fujiwara, M., Satoh, H., Fujimoto, M., Yazawa, T., Ishikawa, H., Horiguchi, H., Ogata, T., Matsui, M., Kamma, H. Anticancer Res. (1998) [Pubmed]
  2. Assessing the differentiation state of cultured bovine urothelial cells: elevated synthesis of stratification-related K5 and K6 keratins and persistent expression of uroplakin I. Surya, B., Yu, J., Manabe, M., Sun, T.T. J. Cell. Sci. (1990) [Pubmed]
  3. Dissociation of cytochrome c from liposomes by histone H1. Comparison with basic peptides. Rytömaa, M., Kinnunen, P.K. Biochemistry (1996) [Pubmed]
  4. Expression of simple epithelial cytokeratins in bovine pulmonary microvascular endothelial cells. Patton, W.F., Yoon, M.U., Alexander, J.S., Chung-Welch, N., Hechtman, H.B., Shepro, D. J. Cell. Physiol. (1990) [Pubmed]
  5. Mixed apocrine sweat gland tumor of the tail in a cow. Gulbahar, M.Y., Alkan, I., Aslan, L., Golen, I. Vet. Pathol. (2002) [Pubmed]
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