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Gene Review:

RAB14 - RAB14, member RAS oncogene family

Homo sapiens

Synonyms: FBP, RAB-14, Ras-related protein Rab-14

Predic, J. et al., Junutula, J.R. et al., Ishikura, S. et al., Zhang, D. et al.

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High impact information on RAB14

Rab14 is involved in membrane trafficking between the Golgi complex and endosomes [1].
By immunofluorescence and immunoelectron microscopy, both endogenous as well as overexpressed Rab14 were localized to biosynthetic (rough endoplasmic reticulum, Golgi, and trans-Golgi network) and endosomal compartments (early endosomal vacuoles and associated vesicles) [1].
There was a wide range of different kinetic behavior, and groups of functionally linked proteins such as Rab14, nucleophosmin,and cyclin-dependent kinase inhibitor 1B could be detected from similar kinetics [2].
The observed proteins included unexpected proteins such as Sox5, two isoforms of Rab14, Rab3A, translationally controlled tumor protein, and one protein of previously unknown function [2].
Coexpression of GFP-tagged Rabs 8A or Rab14 with 4P-AS160 prevented the inhibition of GLUT4 translocation imposed by 4P-AS160 [3].

Biological context of RAB14

Both the dose- and time-dependent up-regulation of Hsp70 protein 8 and heterogeneous nuclear ribonucleoprotein (hnRNP) H1, and the down-regulation of Rab14, hnRNP C and stathmin-1 by GEN were verified by immunoblot analysis [4].

Anatomical context of RAB14

These results suggest that Rab8A and possibly Rab14 may be targets of AS160 leading to GLUT4 translocation in L6 muscle cells [3].

References

Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. Junutula, J.R., De Maziére, A.M., Peden, A.A., Ervin, K.E., Advani, R.J., van Dijk, S.M., Klumperman, J., Scheller, R.H. Mol. Biol. Cell (2004) [Pubmed]
Monitoring of gene expression by functional proteomics: response of human lung fibroblast cells to stimulation by endothelin-1. Predic, J., Soskic, V., Bradley, D., Godovac-Zimmermann, J. Biochemistry (2002) [Pubmed]
Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells. Ishikura, S., Bilan, P.J., Klip, A. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
Molecular response of leukemia HL-60 cells to genistein treatment, a proteomics study. Zhang, D., Tai, Y.C., Wong, C.H., Tai, L.K., Koay, E.S., Chen, C.S. Leuk. Res. (2007) [Pubmed]

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RAB14	Bos taurus
RAB14	Canis lupus familiaris
rab14l	Danio rerio
RAB14	Gallus gallus
RAB14	Macaca mulatta
MGG_07191	Magnaporthe oryzae 70-15
Rab14	Mus musculus
NCU01647	Neurospora crassa OR74A
RAB14	Pan troglodytes
Rab14	Rattus norvegicus
rab14	Xenopus (Silurana) tropicalis

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