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PADI3  -  peptidyl arginine deiminase, type III

Homo sapiens

Synonyms: PAD3, PDI3, Peptidylarginine deiminase III, Protein-arginine deiminase type III, Protein-arginine deiminase type-3
 
 
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High impact information on PADI3

  • Following a comparison of our data with SNPs in the dbSNP database in the National Center for Biotechnology Information, 45 SNPs are considered to be novel: 33 were identified in the PADI1 gene locus and 12 in the PADI3 gene locus [1].
  • NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes [2].
  • These data indicate that PADI3 expression is driven by Sp1/Sp3 and NF-Y binding to the promoter region [2].
  • Human peptidylarginine deiminase type III gene (PADI3) encodes a crucial post-translational modification enzyme that converts protein-bound arginine residues into citrulline residues [2].
  • Furthermore, Sp1 or NF-YA (NF-Y subunit) small interfering RNAs effectively diminished PADI3 expression in keratinocytes cultured in both low- and high-calcium medium [2].
 

Biological context of PADI3

References

  1. Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13. Iida, A., Nakamura, Y. J. Hum. Genet. (2004) [Pubmed]
  2. NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes. Dong, S., Kanno, T., Yamaki, A., Kojima, T., Shiraiwa, M., Kawada, A., Méchin, M.C., Chavanas, S., Serre, G., Simon, M., Takahara, H. Biochem. J. (2006) [Pubmed]
 
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