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Gene Review

Srpx  -  sushi-repeat-containing protein

Mus musculus

Synonyms: DRS protein, Sushi-repeat-containing protein SRPX, drs, drs-1, drs-2, ...
 
 
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Disease relevance of Srpx

  • Between 7 and 12 months after birth, malignant tumors including lymphomas, lung adenocarcinomas and hepatomas were generated in about 30% of the drs KO mice, whereas no tumors were found in any of the wild-type mice during the same period of time. drs KO embryonic fibroblasts also showed enhanced sensitivity to transformation by v-src oncogene [1].
 

High impact information on Srpx

  • The present results thus indicate that drs contributes to the suppression of malignant tumor formation, and this suppression is closely correlated with drs-mediated apoptosis [1].
  • Expression of drs mRNA is markedly downregulated in a variety of human cancer cell lines and tissues, suggesting the potential role of this gene as a tumor suppressor [1].
  • Reintroduction of drs into a tumor cell line derived from the tumor of a drs KO mouse led to the suppression of tumor formation in nude mice, which was accompanied by enhanced apoptosis and the activation of caspase-9 and -3 [1].
  • Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs [1].
  • Previously, we found that Drs protein associates with ASY/Nogo-B/RTN-x(S), an apoptosis-inducing protein in the endoplasmic reticulum, and sequentially activates caspases to induce apoptosis in human cancer cells without involvement of the mitochondria [1].
 

Biological context of Srpx

  • The drs gene was isolated as a transformation suppressor against the v-src oncogene [2].
  • Isolation of a novel mouse variant of the drs tumor suppressor gene [2].
  • In this study, we investigated the tumor suppressor function of drs and the correlation between Drs-mediated apoptosis and tumor suppression by generating a gene-knockout (KO) mouse [1].
 

Anatomical context of Srpx

  • The drs gene also has the ability to suppress anchorage-independent growth of human cancer cell lines [2].

References

  1. Tumor prone phenotype of mice deficient in a novel apoptosis-inducing gene, drs. Tambe, Y., Yoshioka-Yamashita, A., Mukaisho, K., Haraguchi, S., Chano, T., Isono, T., Kawai, T., Suzuki, Y., Kushima, R., Hattori, T., Goto, M., Yamada, S., Kiso, M., Saga, Y., Inoue, H. Carcinogenesis (2007) [Pubmed]
  2. Isolation of a novel mouse variant of the drs tumor suppressor gene. Kawai, T., Suzuki, Y., Yamashita, A., Inoue, H. Cancer Lett. (2002) [Pubmed]
 
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