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Gene Review

Batf  -  basic leucine zipper transcription factor,...

Mus musculus

Synonyms: B-ATF, B-cell-activating transcription factor, Basic leucine zipper transcriptional factor ATF-like, SFA-2
 
 
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Disease relevance of Batf

 

High impact information on Batf

  • BATF forms complexes with c-Jun in M1 cells and forced expression of BATF in the absence of Stat3 signaling results in a reduced rate of cellular growth [2].
  • In addition, the unique circumstances of this regulation were exploited to demonstrate that inhibition of AP-1 activity by BATF exerts a direct, and reversible, effect on T cell proliferation in vitro [3].
  • The responsiveness to PMA and ionomycin can be attributed to the dramatic disappearance of the hemagglutinin antigen (HA)-tagged BATF protein which is a PKC-dependent process caused by the down-regulation of the p56(lck) proximal promoter coupled with the rapid turnover of the HA-BATF protein [3].
  • Mice carrying a p56(lck)HA-BATF transgene were created to observe the effects of constitutive expression of this well-characterized AP-1 inhibitor on T cell proliferation [3].
  • Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus [4].
 

Biological context of Batf

 

Anatomical context of Batf

  • BATF mRNA levels are regulated differentially during discrete stages of T cell development and are up-regulated following activation of T cells in the periphery [4].
 

Other interactions of Batf

  • A novel integration cluster between Jdp2 and Batf apparently did not influence the expression level of either gene, underscoring the importance of addressing expression effects to identify target genes of insertion [1].

References

  1. Tumor model-specific proviral insertional mutagenesis of the Fos/Jdp2/Batf locus. Rasmussen, M.H., Sørensen, A.B., Morris, D.W., Dutra, J.C., Engelhard, E.K., Wang, C.L., Schmidt, J., Pedersen, F.S. Virology (2005) [Pubmed]
  2. Stat3-dependent induction of BATF in M1 mouse myeloid leukemia cells. Senga, T., Iwamoto, T., Humphrey, S.E., Yokota, T., Taparowsky, E.J., Hamaguchi, M. Oncogene (2002) [Pubmed]
  3. Direct manipulation of activator protein-1 controls thymocyte proliferation in vitro. Thornton, T.M., Zullo, A.J., Williams, K.L., Taparowsky, E.J. Eur. J. Immunol. (2006) [Pubmed]
  4. Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus. Williams, K.L., Nanda, I., Lyons, G.E., Kuo, C.T., Schmid, M., Leiden, J.M., Kaplan, M.H., Taparowsky, E.J. Eur. J. Immunol. (2001) [Pubmed]
 
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